Studies on Biologically Active Nucleosides and Nucleotides. IV. : Synthesis of 1-β-D-Arabinofuranosyl-2-aralkylamino-1,4-dihydro-4-iminopyrimidine Hydrochlorides
スポンサーリンク
概要
- 論文の詳細を見る
Some 1-β-D-arabinofuranosyl-2-aralkylamino-1,4-dihydro-4-iminopyrimidine hydrochlorides (2a-c) were prepared by the reaction of 2,2'-anhydro-1-(β-D-arabinofuranosyl)-cytosine hydrochloride (1) with the corresponding aralkylamines (1 equiv.) in methanol. Treatment of 1 with an excess of the amines gave 1-β-D-arabinofuranosyl-2-aralkylamino-1,4-dihydro-4-aralkyliminopyrimidine hydrochlorides (3a, b). These compounds were inactive against leukemia L-1210 and Ehrlich carcinoma in mice.
- 社団法人日本薬学会の論文
- 1978-10-25
著者
-
近藤 一彦
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,
-
近藤 一彦
Research Laboratories Of Tanabe Seiyaku Co. Ltd.
-
小島 明広
Research Laboratories of Tanabe Seiyaku Co., Ltd.
-
井上 一三
Research Laboratories of Tanabe Seiyaku Co., Ltd.
-
小島 明広
Research Laboratories Of Tanabe Seiyaku Co. Ltd.
-
井上 一三
Research Laboratories Of Tanabe Seiyaku Co. Ltd.
関連論文
- Practical Synthesis of Optically Pure 1- and 3-Substituted Dihydroorotic Acids
- Studies on Biologically Active Nucleosides and Nucleotides. IV. : Synthesis of 1-β-D-Arabinofuranosyl-2-aralkylamino-1,4-dihydro-4-iminopyrimidine Hydrochlorides
- The Synthesis of Chromone-3-carboxanilides
- 121.ビタミンB_6誘導体の研究(XIII) : ピリドキシル-デヒドロホモシステインチオラクトンの合成(一般研究発表要旨)
- ビタミンB_6誘導体の研究 : (X)ピリドキサールおよびピリドキサールリン酸とホモシステインエステルの結合化合物の合成とその理化学的性質
- Arylnaphthalene Lignans as Novel Series of Hypolipidemic Agents Raising High-Density Lipoprotein Level
- 2,2'-Disubstituted Biphenyls : Synthesis and Suppressive Effect against Carbon Tetrachloride-Induced Liver Injury
- A Synthesis of 2-Substituted 2-Aminoethanol Derivatives Having Inhibitory Activity against Protein Kinase C
- 2,2'-Disubstituted Biphenyls : Synthesis and Suppressive Effect against Carbon Tetrachloride-Induced Liver Injury
- 2,2'-Disubstituted Biphenyls : Synthesis and Suppressive Effect against Carbon Tetrachloride-Induced Liver Injury
- Synthetic Studies on 2-Pyrrolidinone Derivatives. II. The Configuration of Stereoisomers of 1-Phenyl-3-amino-5-methyl-2-pyrrolidinone.
- Studies on biologically Active Halogenated Compounds. II. Chemical Modifications of 6-Amino-2-fluoromethyl-3-(o-tolyl)-4 (3H)-quinazolinone and the CNS Depressant Activities of Related Compounds
- 4-Oxo-1,2,3,4-tetrahydroquinazoline. IV. Reactions of 2-Chloromethyl-3-aryl-4-oxo-1,2,3,4-tetrahydroquinazolines
- 29.ビタミンB_6誘導体の研究 : (II)PyridoxalおよびPyridoxal phosphateとDL-Homocysteine結合化合物エステル類合成(一般研究発表要旨)
- Synthetic Studies on 2-Pyrrolidinone Derivatives. I. Synthesis of 1-Phenyl-3-dialkylamino-2-pyrrolidinone and its 5-Methyl Analog.