Quinazolin-2ones Having a Spirohydantoin Ring. II. Synthesis of Several Spiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2', 5(3'H)-triones via 5-Hydroxyhydantoin Derivatives
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概要
- 論文の詳細を見る
Reaction of 1-ethoxycarbonylisatin (1b) with urea gave 5-(2-ethoxycarbonylaminophenyl)-5-hydroxyhydantoin (4b) in a good yield. Treatment of 4b with several amines directly gave the corresponding spiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2', 5(3'H)-trione derivatives (7a-d) in moderate yields. 3-Unsubstituted and 3-methylspiroquinazolin-2-one derivatives 7a, b were also synthesized from 5-ethoxy and 5-ethylthiohydantoins 5a, d, which in turn were easily obtained by the reaction of either ethanol or ethylmercaptan with 4b in the presence of a catalytic amount of sulfuric acid.
- 社団法人日本薬学会の論文
- 1991-03-25
著者
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鈴木 護
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,
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山岸 正文
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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山田 義久
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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尾崎 建一
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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鈴木 護
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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