Synthesis and Central Nervous System Actions of Thyrotropin-Releasing Hormone Analogs Containing a 1-Oxo-1,2,3,4-tetrahydroisoquinoline Moiety
スポンサーリンク
概要
- 論文の詳細を見る
In order to find compounds having selective central nervous system (CNS) actions, various thyrotropin-releasing hormone (TRH) analogs in which the pyroglutamic acid residue is replaced by (3S)-1-oxo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Otc-OH) and related derivatives were prepared and their CNS actions were investigated in mice.Otc-His-Pro-NH_2 (9a) showed 3.5-10 times stronger CNS actions than TRH (1). However, it was also 3-4 times more potent than TRH in thyrotropin (TSH)-releasing activity.
- 公益社団法人日本薬学会の論文
- 1988-01-25
著者
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鈴木 護
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,
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前田 ひろし
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,
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菅野 紘
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,
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鈴木 護
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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山村 道夫
Safety Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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石田 柳一
Safety Reseach Laboratory
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石田 柳一
Safety Reseach Laboratory:tanabe Seiyaku Co. Ltd.
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山村 道夫
Safety Reseach Laboratory:tanabe Seiyaku Co. Ltd.
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前田 ひろし
Faculty Of Pharmaceutical Sciences Osaka University
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菅野 紘
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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