Syntheses of 2-Aryl-4-(3-thienyl)imidazole Derivatives with Antiinflammatory Preperties
スポンサーリンク
概要
- 論文の詳細を見る
A series of 2-substituted 4-(3-thienyl)imidazoles (6,11,and 14) was synthesized and evaluated for antiinflammatory activity. Among them, 6g, 14a, and 14g exhibited strong activity, comparable to that of ibuprofen. The acute toxicity and the ulcerogenicity were low as compared with those of standard acidic antiinflammatory agents. The structure-activity relationships are discussed.
- 社団法人日本薬学会の論文
- 1986-08-25
著者
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松本 和男
田辺製薬医薬育成所
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松本 和男
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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鈴木 護
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,
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前田 貞夫
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.,
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石塚 徹
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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岩澤 義郎
Biological Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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岩澤 義郎
Biological Research Laboratory Tanabe Seiyaku Co. Ltd.
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鈴木 護
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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前田 貞夫
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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石塚 徹
Biological Research Laboratory Tanabe Seiyaku Co. Ltd.
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