Bis型ビタミンB_1誘導体, Cyclobismethylenethiamineについて : (II)ラネーニッケルによる脱硫反応
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概要
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In order to confirm the structure of CBMT (II), desulfurization of II with Raney Ni was carried out, and then a desulfurized product (IV), mp 110-112°, was obtained. As a comparative experiment, TDS (III) and trans-S-butyl thiamine (VI) gave the corresponding desulfurized products (V) and (VII), respectively by the similar procedure. From the result of acid hydrolysis and physical data of the desulfurized products, the structure of IV was determined to be cis-N-[(2-methyl-4-methylaminopyrimidin-5-yl) methyl]-N-(1-methyl-4-hydroxy-1-butenyl)-formamide. The structure of CBMT was consequently confirmed as III proposed in the previous paper from above results.
- 1971-11-25
著者
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米田 直人
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.
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米田 直人
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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米田 直人
田辺製薬株式会社東京研究所
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萩尾 克明
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co., Ltd.
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安尾 悠紀
田辺製薬株式会社化成研究所
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萩尾 克明
田辺製薬株式会社化成研究所
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萩尾 克明
Research Laboratory Of Applied Biochemistry Tanabe Seiyaku Co. Ltd.
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