ビタミンB_6誘導体の研究 : (XII)ピリドキサール-ホモシステイン投与時の尿中アミノ酸の変化

概要

論文の詳細を見る
The excessive doses of 100 or 50mg/100g of pyridoxal-DL-homocysteine (PAL-HCySH), pyridoxal hydrochloride (PAL-HCl) and DL-homocysteine (HCySH) were administered to the rats fed with vitamin B_6-deficient diet during 6 weeks. Subacute lethalities, body weights and general toxic symptoms of the rats were observed. Amino acids in urine and plasma were determined, also. PAL-HCySH has smaller toxicity than PAL-HCl. Amino acids in 24 hours urine showed that taurine, cysteic acid were much larger than the others, in rats with administered PAL-HCySH and HCySH. Cystathionine was excreted in urine of vitamin B_6-deficient rats, and did not change by an application of HCySH but disappeared by PAL-HCySH or PAL-HCl. HCySH in PAL-HCySH molecule did not exist in the body, but it was changed to metabolite of the sulfur containing amino acids.
1968-10-25