Protection by flunarizine from deterioration of hippocampal neurons following exposure to high potassium media.

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概要

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• Flunarizine, a Ca-antagonist, at a concentration of 1μM reversibly depressed Ca-dependent spikes without affecting the resting membrane properties of guinea-pig hippocampal neurons. Flunarizine (1μM) did not affect the EPSPs evoked by focal stimuli, but slightly reduced the duration of evoked IPSPs. When the neurons were superfused with high K<SUP>+</SUP> (60-75 mM) solutions, the membrane potential was irreversibly reduced to approximately 0 mV. The cell deterioration could be prevented by the addition of Co<SUP>2+</SUP> (2mM), a specific Ca<SUP>2+</SUP> channel blocker, to the superfusing solution. Addition of flunarizine (1 μM) also prevented the high K<SUP>+</SUP> induced deterioration. These results indicate that the blockade of voltage dependent Ca<SUP>2+</SUP>- influxes by flunarizine prevents the cell deterioration induced by K<SUP>+</SUP>-rich media.

• 久留米大学医学部 The Kurume Medical Journal 編集部の論文

著者

• Higashi Hideho

  Department Of Physiology Kurume University School Of Medicine

• Sugita Shunsuke

  Department Of Neurosurgery Kurume University School Of Medicine

• NISHI SYOGORO

  Department of Physiology Kurume University School of Medicine

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