THE β-ADRENERGIC RESPONSES IN ISOLATED SPLENIC CAPSULE AREA OF SEVERAL SPECIES OF ANIMALS
スポンサーリンク
概要
- 論文の詳細を見る
In isolated splenic capsules of mouse, rat, guinea pig, rabbit, cat and dog, either a single or a cumulative dose of l-and dl-isoproterenol at a concentration higher than 10<SUP>-9</SUP> M, induced a relaxation which was inhibited or blocked with pretreatment of 10<SUP>-5</SUP> M propranolol. At a concentration of 5 × 10<SUP>-6</SUP> M to 10<SUP>-5</SUP> M l- and dl-isoproterenol, an inverse contraction was induced, and such response was prevented or reversed to one of relaxation in the presence of 10<SUP>-5</SUP> M phentolamine. Application of 10<SUP>-5</SUP> M epinephrine produced a strong contraction and such was reversed to one of relaxation after addition of 10<SUP>-4</SUP> M phentolamine. This relaxation was reduced or blocked with pretreatment of 10<SUP>-5</SUP> M propranolol. Thus, it was confirmed that both α- and β-receptors exist in the splenic capsule area of these different species.
- 社団法人 日本薬理学会の論文
著者
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Tang Li
Department Of Applied Physics Chung Cheng Institute Of Technology University Of National Defense:ins
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TAKASAKI KOICHIRO
Department of Pharmacology, Miyazaki Medical College
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URABE Masanobu
Department of Pharmacology, Miyazaki Medical College
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Takasaki Koichiro
Department Of Pharmacology Miyazaki Medical College
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TANG Li
Department of Pharmacology, Miyazaki Medical College
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