Different Effects of Cinnamic Acid on the O_2-Generation by Guinea Pig Macrophages Stimulated with a Chemotactic Peptide and Immune Complex

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Cinnamic acid inhibits the O^-_2-generating response of guinea pig peritoneal macrophages elicited with a chemotactic peptide, N-formyl-methionyl-leucyl-phenylalanine (fMLP), but not those with ovalbumin complex of immunoglobulin G_2 antibody and phorbol-myristate acetate. ^<1)>During the course of study on the inhibitory mechanism of cinnamic acid, we found that the acid also inhibited the Ca^<2+> mobilization elicited with fMLP, but not that with the immune complex. In addition, the treatment of macrophages with Ionomycin and ethyleneglycol bis-(β-aminoethylether)-N, N'-tetraacetic acid for depletion of the intracellular Ca^<2+> inactivated completely the O^-_2generation elicited with fMLP, but not its counterpart of the immune complex. Thus, the inhibitory activity of cinnamic acid on the O^-_2generation elicited with fMLP seems partly due to that on the Ca^<2+> mobilization. On the other hand, cinnamic acid augmented the intracellular accumulation of adenosine 3', 5'-cyclic monophosphate (cyclic AMP) in the presence of 3-isobutyl 1-methylxanthine (IBMX), and elevated more intensively the concentration of cyclic AMP when macrophages were stimulated with fMLP. Since IBMC inhibited the O^-_2generation elicited with fMLP, the enhancement of activation of an adenylate cuclase by cinnamic acid might cause depression of the O^-_2generation. This possibility, however, seems to be excluded by the fact that the same effect of cinnamic acid was observed even when macrophages were stimulated with the immune complex.
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Different Effects of Cinnamic Acid on the O_2-Generation by Guinea Pig Macrophages Stimulated with a Chemotactic Peptide and Immune Complex

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