Effect of Dilazep on Myocardial Contractility Following Acute Ischemia and Reperfusion in Isolated Blood-Perfused Canine Left Ventricular Muscle

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概要

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• Myocardial protection by dilazep HCl, an antianginal drug and a potent calcium antagonist, against myocardial damage following acute ischemia and reperfusion was studied with respect to myocardial contractility in isolated blood-perfused canine left ventricular muscle. Myocardial function was expressed by percent recovery rate of maximal net developed tension. 1) The coronary infusion of dilazep revealed significant myocardial protection during normothermic ischemic arrest of 45 min and reperfusion. 2) The intravenous administration of dilazep to the support dog and Youngs infusion also showed significant myocardial protection during normothermic ischemic arrest of 45 min and reperfusion. Dilazep showed no persistent depression of myocardial contractility due to its calcium antagonistic effect during reperfusion. 3) The combination of intravenous administration of dilazep to the support dog, Youngs infusion, and hypothermia showed significant myocardial protection during prolonged ischemia and reperfusion even in hypertrophied ventricle. These results demonstrate that dilazep provides effective myocardial protection during ischemic arrest and repefusion by preventing abnormal calcium accumulation in myocardial cells during reperfusion. No persistent depression of myocardial contractility during reperfusion may support dilazeps clinical application as a myocardial protective agent in open-heart surgery

• International Heart Journal刊行会の論文

著者

• SHIDA Hiroshi

  Second Department of Surgery, Shinshu University School of Medicine

• KOBAYASHI Miyoharu

  Research Laboratory for Cardiovascular Diseases and Department of Pharmacology, School of Medicine,

• CHIBA Shigetoshi

  Research Laboratory for Cardiovascular Diseases and Department of Pharmacology, School of Medicine,

• SHIDA Hiroshi

  Second Department of Surgery, Faculty of Medicine, Shinshu University

• CHIBA Shigetoshi

  Research Laboratory for Cardiovascular Diseases and Department of Pharmacology, School of Medicine, Shinshu University

• KOBAYASHI Miyoharu

  Research Laboratory for Cardiovascular Diseases and Department of Pharmacology, School of Medicine, Shinshu University

関連論文

• EXPERIMENTAL STUDIES ON MYOCARDIAL METABOLISM OF CARBOHYDRATE AND LIPID IN SURFACE-INDUCED DEEP HYPOTHERMIA
• Angiotensin II-Induced Myocardial Damage with a Special Reference to Low Cardiac Output Syndrome
• Effect of Dilazep on Myocardial Contractility Following Acute Ischemia and Reperfusion in Isolated Blood-Perfused Canine Left Ventricular Muscle
• Effect of Hypothermic Anoxic Arrest on Myocardial Contractility in the Isolated Blood-Perfused Canine Left Ventricular Muscle

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