Antiemetic Effects of Serotonergic 5-HT1A-Receptor Agonists in Suncus Murinus.
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概要
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The antiemetic effects of six serotonergic 5-HT<SUB>1A</SUB>-receptor agonists, 8-hydroxy-2-(di-<I>n</I>-propylamino)tetrarin (8-OH-DPAT), 4-{4-[4-(2-pyrimidinyl)piperazin-l-yl]butyl}-2, 3, 4, 5-tetrahydro-l, 4-benzo-xazepine-3, 5-dione (SUN8399), buspirone, gepirone, ipsapirone and tandospirone, against motion sickness were investigated in <I>Suncus murinus</I>. Subcutaneous injection of all six agonists completely and dose-dependently suppressed motion-induced emesis. Pretreatment with 8-OH-DPAT or SUN8399 dose-dependently inhibited emesis elicited by nicotine (4.0 mg/kg, s.c.), veratrine (0.7 mg/kg, s.c.), cisplatin (20 mg/kg, i.p.) and copper sulfate (40 mg/kg, p.o.). These results suggest that serotonergic 5-HT<SUB>1A</SUB>-receptor agonists are effective as anti-motion sickness drugs, and these drugs may block a common mechanism(s) for the emetic reflex of the suncus because the antiemetic effects of the 5-HT<SUB>1A</SUB>-receptor agonists were exerted irrespective of the stimulus.
- 公益社団法人 日本薬理学会の論文
著者
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Matsuki Norio
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Science The University Of Tokyo
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Saito Hiroshi
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
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Torii Yoshifumi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Science, The University of Tokyo
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Okada Fumihiko
Department of Chemical Pharmacology, Faculty of Pharmaceutical Science, The University of Tokyo
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Saito Hiroshi
Department of Applied Chemistry, Graduate School of Engineering, Tohoku University
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