Cisplatin-Induced Emesis in Suncus Murinus.
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概要
- 論文の詳細を見る
Emetic responses to cisplatin and participation of vagal innervation in emesis were studied in suncus. Intraperitoneal and intravenous administration of cisplatin caused dose-dependent emesis. ED<SUB>50</SUB> values, latencies and frequencies were not significantly different between the two administrations. Cis-diagodiammineplatinum (DAP), an active metabolite of cisplatin, also induced emesis, but with significantly shorter latency. Vagotomy completely abolished both types of vomiting. These results suggest that cisplatin is metabolized to DAP that subsequently causes emesis through stimulation of the vagus afferent.
- 公益社団法人 日本薬理学会の論文
著者
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Matsuki Norio
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Science The University Of Tokyo
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Mutoh Masato
Basic Research Laboratories Toray Inductries Inc.
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Imanishi Hideyo
Basic Research Laboratories Toray Inductries Inc.
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Saito Hiroshi
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
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Mutoh Masato
Basic Research Laboratories, Toray Industries, Inc.
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Torii Yoshifumi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
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Tamura Mitsutaka
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
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Torii Yoshifumi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Science, The University of Tokyo
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Saito Hiroshi
Department of Applied Chemistry, Graduate School of Engineering, Tohoku University
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Imanishi Hideyo
Basic Research Laboratories, Toray Industries, Inc.
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