Soluble Guanylyl Cyclase Inhibitor Prevents Sema3F-Induced Collapse of Axonal and Dendritic Growth Cones of Dentate Granule Cells(Molecular and Cell Biology)

概要

論文の詳細を見る
Controlling axon and dendrite elongation is critical in developing precise neural circuits. Using isolated cultures of dentate granule neurons, we succeeded in simultaneously monitoring the behaviors of axonal and dendritic outgrowth. Our previous study shows that cAMP contributes differentially to Sema3F-induced responses of axons and dendrites, but we report here that the cGMP modulation does not have such a striking axo-dendritic difference. Treatment with Sema3F induced collapse of about 90% growth cones, and pretreatment with 1μM LY83583, an inhibitor of soluble guanylyl cyclase, partially alleviated the collapse of both axons and dendrites. Thus, unlike cAMP, cGMP modulates axonal and dendritic extension in a similar manner.
公益社団法人日本薬学会の論文
2006-04-01