Myo-Inositol Treatment Increases Serum Plasmalogens and Decreases Small Dense LDL, Particularly in Hyperlipidemic Subjects with Metabolic Syndrome
スポンサーリンク
概要
- 論文の詳細を見る
Background and aim: We have previously shown that serum plasmalogen levels positively correlate with HDL, and significantly decrease with aging, and may be related to LDL particle size. The objective of the present study was to investigate the effects of increased serum plasmalogens on lipidosis, particularly the appearance of atherogenic small dense LDL (sdLDL), of subjects with hyperlipidemia and metabolic syndrome (MetS). Methods and results: The effects of increased serum plasmalogen levels, induced by 2 wk of myoinositol treatment, on several clinical and biochemical parameters were examined in 17 hyperlipidemic subjects including some with MetS. After myo-inositol treatment, significant increases in plasmalogen-related parameters, particularly ChoPlas, and significant decreases in atherogenic cholesterols including sdLDL, were observed. Among the hyperlipidemic subjects treated with myo-inositol, compared to subjects without MetS, subjects with MetS had a significant increase in plasmalogens and a tendency towards reduced sdLDL, high sensitivity C-reactive protein (hsCRP), and blood glucose levels. Correlation analyses between the measured parameters showed that plasmalogens, as well as HDL, function as beneficial factors, and that sdLDL is a very important risk factor that shows positive correlations with many other risk factors. Conclusion: These results suggest that increased plasmalogen biosynthesis and/or serum levels are especially effective in improving MetS among hyperlipidemic subjects with MetS.
- 日本ビタミン学会の論文
著者
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Kinoshita Makoto
Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital
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TERAMOTO Tamio
Department of Internal Medicine, Teikyo University
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Kinoshita Makoto
Dep. Of Internal Medicine Teikyo Univ. School Of Medicine
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Kinoshita M
Committee For Epidemiology And Clinical Management Of Atherosclerosis
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Kinoshita M
Dep. Of Internal Medicine Teikyo Univ. School Of Medicine
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YOSHIMURA Nakayuki
Department of Internal Medicine, Teikyo University School of Medicine
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TAKEOKA Yoko
Department of Internal Medicine, Teikyo University School of Medicine
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YASUDA Daijiro
Department of Internal Medicine, Teikyo University School of Medicine
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Teramoto T
Dep. Of Internal Medicine Teikyo Univ. School Of Medicine
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Teramoto Tamio
帝京大学 医学部内科
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Teramoto Tamio
Department Of Internal Medicine Teikyo University School Of Medicine
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KINOSHITA Makoto
Committee for Epidemiology and Clinical Management of Atherosclerosis
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KUSANO Jyun
Department of Internal Medicine, Teikyo University School of Medicine
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Kinoshita Makoto
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Kusano Jyun
Department Of Internal Medicine Teikyo University School Of Medicine
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Yasuda Daijiro
Department Of Internal Medicine Teikyo University School Of Medicine
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OKAZAKI TOMOKI
Departments of Endocrinology and Nephrology, University of Tokyo School of Medicine
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Okazaki Tomoki
Department Of Biochemistry Teikyo University School Of Medicine
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Hayashi Shigeru
Hayashi Clinic
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MAEBA Ryouta
Department of Biochemistry, Teikyo University School of Medicine
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HARA Hiroshi
Graduate School of Agriculture, Hokkaido University
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ISHIKAWA Hiroshi
Hokkaido Sugar Co., Ltd.
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Teramoto Tamio
First Department Of Internal Medicine Teikyo University School Of Medicine
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Motoyoshi Kentaro
Division Of Cardiology Teikyo University School Of Medicine
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Yoshimura Nakayuki
Department Of Internal Medicine Teikyo University School Of Medicine
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Maeba Ryouta
Department Of Biochemistry Teikyo University School Of Medicine
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Takeoka Yoko
Department Of Internal Medicine Teikyo University School Of Medicine
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Hara Hiroshi
Graduate School Of Agriculture Hokkaido University
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Ishikawa Hiroshi
Hokkaido Sugar Co. Ltd.
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Okazaki Tomoki
Department Of Biochemistry Teikyo Medical University
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Kinoshita Makoto
Department of Applied Chemistry for Resources, Tokyo University of Agriculture and Technology
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