痙れん性マイコトキシンの化学

概要

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The diseases caused by the ingestion of mycotoxins are known as mycotoxicosis. Mycotoxins are occasionally very hazardous to us and domestic animals when we and animals take daily foods or feeds infested by toxin-producing fungi. Most mycotoxins are hepatotoxic or nephrotoxic however some of them cause neurologic disease of animals. For instance, citreoviridin is a yellow metabolite <I>Penicillium citreo-viride</I> and causes paralysis in the laboratory animals often followed by convulsion and respiratory arrest. This toxin is suspected by Japanese researchers to be a probable causative factor for acute cardiac beriberi. In this article, a general concept on mycotoxicosis is firstly related and the outline of our study on the tremorgenic toxins is then described. In addition to fumitremorgin A and B which are the tremorgenic toxins newly isolated from <I>Aspergillus fumigatus</I> in our laboratory, the isolation of verruculogen, roquefortin and paxilline have been reported. The structural relations between these toxins and their biological activities are also reviewed.
社団法人有機合成化学協会の論文