Studies on RA Derivatives. V. Synthesis and Antitumor Activity of Ala^2-Modified RA-VII Derivatives
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概要
- 論文の詳細を見る
A number of RA-VII derivatives having various amino acids including proline (6), pipecolic acid (11), norvaline (12), ornithine (14), aspartic acid (15) and methionine (20) in place of Ala^2 have been synthesized from RA-X methyl ester (3) and evaluated for cytotoxicity to P388 leukemia and KB cells in vitro. Comparison of the cytotoxicity of these compounds suggests that the polarity and the length of the 2nd amino acid residue affect the activity. An NMR study revealed that, in solution, 6 and 11 are locked in one conformational state, corresponding to conformer A of RA-VII.
- 社団法人日本薬学会の論文
- 1993-08-15
著者
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一柳 幸生
東京薬大薬
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竹谷 孝一
東京都立衛生研究所
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糸川 秀治
Tokyo College Of Pharmacy
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竹谷 孝一
東京薬大薬
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糸川 秀治
東京薬科大学 薬学部
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磯村 めぐみ
Tokyo College Of Pharmacy
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竹谷 孝一
Tokyo College of Pharmacy
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近藤 和行
Tokyo College of Pharmacy
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一柳 幸生
Tokyo College of Pharmacy
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