Structures and Conformations of Metabolites of Antitumor Cyclic Hexapeptides, RA-VII and RA-X
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概要
- 論文の詳細を見る
Metabolites of antitumor cyclic hexapeptides, RA-VII and -X which were isolated from Rubia cordifolia were studied by hepatic microsomal biotransformation in rats and in bile juice of rabbits to which these drugs were administered intravascularly. Their structures and conformations were elucidated by two-dimensional nuclear magnetic resonance techniques, temperature effect on NH protons and nuclear Overhauser effect experiments. Specific N-demethylation of Tyr-3,O-demethylation and hydroxylation at aromatic rings of Tyr-3 and -5 were observed. Compared with metabolites of RA-VII, most of RA-X was excreted unchanged in the bile juice. Relationship among their structures, conformations and antitumor activities is also discussed.
- 公益社団法人日本薬学会の論文
- 1992-11-25
著者
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森田 博史
Department of Pharmacognosy, Tokyo College of Pharmacy
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竹谷 孝一
Department of Pharmacognosy, Tokyo College of Pharmacy
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糸川 秀治
Department of Pharmacognosy, Tokyo College of Pharmacy
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森田 博史
Department Of Pharmacognosy School Of Pharmacy Tokyo University Of Pharmacy And Life Sciences
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竹谷 孝一
東京都立衛生研究所
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糸川 秀治
東京薬科大学 薬学部
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森田 博史
東京薬科大学
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山田 健二
Department of Physiology and Pharmacology
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山田 健二
Laboratory For Pharmaceutical Education Tokyo College Of Pharmacy
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斉藤 敬子
Department Of Pharmacognosy Tokyo College Of Pharmacy
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山田 健二
Department of Pharmacology, Tokyo College of Pharmacy
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