ユーカリノキ(Eucalyptus globulus)の齲蝕原因菌に対する抗菌活性及びグルコシルトランスフェラーゼ阻害効果

概要

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The leaves of Eucalyptus globulus contain unique macrocarpals consisting of a phrologlucinol and sesquiterpene having an antibacterial activity on oral bacteria and an inhibitory effect on glucosyltransferase (GTase). In this paper, a 60% ethanol extract of E. globulus leaves (extract A) and its EtOAc-soluble fraction (extract B) containing most of macrocarpals were examined for the cariostatic effects in vitro. The extracts A and B inhibited the growth of cariogenic bacteria at concentrations of 6.25-50 and 3.13-25 μg/ml, respectively, but their antibacterial activities on the intestinal bacteria were relatively low. The extracts A and B strongly inhibited the glucan synthesis, especially adhesive-insoluble glucan synthesis by GTase prepared from S. sobrinus 6715.
1998-02-20