Some Cytotoxicological Aspects of Ethyl and Fluoroethyl Alkanesulfonates in Escherichia coli : Role of Fluorine Substitution
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概要
- 論文の詳細を見る
Several fluoroethyl derivatives of alkanesulfonates and N-nitrosourea were tested for cytotoxicity and mutagenicity in E. coli K12 AB1157. Cytotoxicity was potentiated by fluorine substitution in the alkyl moiety of the ethylating angents. Mutagenicity was storngly suppressed by fluorine substitution in the alkanesulfonates, but not in the N-nitrosourea.The capacity to induce the SOS repair network was suppressed, as was mutagenicity, in alkanesulfonates, but not in N-nitrosourea. The potentiating effect of fluorine on the cytotoxicity of alkanesulfonates seems to be due to an as yet unknown killing mechanism. An appreciable suppressive effect on the mutagenicity and the SOS induction is worth notice for the biological role of fluorine substitution in alkylating agents.
- 社団法人日本薬学会の論文
- 1991-06-25
著者
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川添 豊
Faculty of Pharmaceutical Sciences, Nagoya City University
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高橋 和彦
横浜薬科大学
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幸田 光復
Faculty of Pharmaceutical Sciences, Nagoya City University
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太田 裕子
Faculty Of Pharmaceutical Sciences Nagoya City University
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幸田 光復
Faculty Of Pharmaceutical Sciences Nagoya City University
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高橋 和彦
Faculty of Pharmaceutical Sciences, Nagoya City University
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川添 豊
Faculty Of Pharmaceutical Sciences Nagoya City University
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高橋 和彦
名市大 院
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高橋 和彦
Faculty Of Pharmaceutical Sciences Nagoya City University
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太田 裕子
名市大院薬
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高橋 和彦
Faculty of Agriculture, Department of Horticulture, University of Tokyo
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