Studies on Chemical Carcinogens and Mutagens. XXXVI. : Apparent Activation Energy for Mutagenic Modification Induced in E. coli by Alkylating Agents. Estimation from Mutation Frequency
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概要
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An attempt was made to establish a procedure for kinetic formulation of the mutagenic chemical modification of the mutational target(s), even though the mutational initiaiton processes are unclear. Using the proposed kinetic formulation, a quantitative analysis was made of the temperature dependence of mutation frequency in terms of the activation energies for mutagenic modification induced in the cell by mutagens. E. coli B Hs30R (uvrA) was treated with alkyl methanesulfonates and N-alkyl-N-nitrosoureas at 37,25 and 15℃ for 1 h and the induced mutation frequencies were normalized in terms of the concentration-time integrated dose. The plot of the normalized mutation frequency versus the reciprocal of the reaction temperature gave a straight line which corresponds to the Arrhenius plot, enabling us to estimate the apparent activation energy of the initial chemical event leading to mutation. It is worth emphasizing that the activation energy evaluated from a certain biological end-point, the mutagenicity in the present study, may cast light on the chemical characteristics of the induced chemical event leading to the end-point concerned.
- 公益社団法人日本薬学会の論文
- 1986-04-25
著者
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川添 豊
Faculty of Pharmaceutical Sciences, Nagoya City University
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羽倉 昌志
Faculty of Pharmaceutical Sciences, Nagoya City University
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川添 豊
Faculty Of Pharmaceutical Sciences Nagoya City University
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羽倉 昌志
Faculty Of Pharmaceutical Sciences Nagoya City University
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