Potentiation of the Cytotoxic Activity of Anti-cancer Drugs against Cultured L1210 Cells by Bacillus thuringiensis subsp. israelensis Toxin

スポンサーリンク

概要

• 論文の詳細を見る

• A 25-kilodaltons (kDa) protein was isolated from the parasporal inclusion produced from Bacillus thuringiensis subsp. israelensis. This 25-kDa protein inhibited the growth of cultured L1210 murine leukemia cells; IC_<50> of the purified 25-kDa protein was 0.9 μg/ml. This toxic protein interacted with membrane constituent lipids. When the 25-kDa protein was used in combination with anti-cancer drugs, their cytotoxicities against cultured L1210 cells were enhanced. Among the anti-cancer drugs tested, the greatest potentiating effect was found in the case of bleomycin. At a non-toxic dose (0.7 μg/ml), the 25-kDa protein potentiated the bleomycin cytoxicity 6.4 fold. Under the conditions used, the order of potentiation among the anti-cancer drugs tested was as follows : bleomycin (6.4 fold), tegafur (4.6), vincristine (4.1), 5-fluorouracil (3.7), vinblastine (3.3), methotrexate (2.5), doxorubicin (2.3), triethylene thiophosphoramide (2.2), neocarzinostatin (2.2) and 1-(4-amino-2 methylpyridine-5-yl)methyl-3-(2-chloroethyl)-3-nitrosourea (1.3). In the case of mitomycin C, the 25-kDa protein was not effective.

• 社団法人日本薬学会の論文
• 1988-11-25

著者

• 川添 豊

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 幸田 光復

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 横山 由美

  Laboratory Of Biochemistry Toa Gosei Chemical Industry

• 川添 豊

  名古屋市立大学薬学部

• 幸田 光復

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 大森 巌

  Laboratory of Biochemistry, Toa Gosei Chemical Industry

• 川添 豊

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 大森 巌

  Laboratory Of Biochemistry Toa Gosei Chemical Industry

関連論文

• 抗生物質の効果比較のための新しい方法
• LIGNIFIED MATERIALS AS MEDICINAL RESOURCES. VI. ANTI-HIV ACTIVITY OF DEHYDROGENATION POLYMER OF p-COUMARIC ACID, A SYNTHETIC LIGNIN, IN A QUASI-IN-VIVO ASSAY SYSTEM AS AN INTERMEDIARY STEP TO CLINICAL TRIALS
• Lignified Materials as Medicinal Resources. V. Anti-HIV (Human Immunodeficiency Virus) Activity of Some Synthetic Lignins)
• Studies on Chemical Carcinogens and Mutagens. XXXIX. : Effects of Silicon and Germanium Substitutions on Physicochemical Properties and Cytotoxicity of N-Alkyl-N-nitrosoureas
• 医薬分業における薬学教育のあり方
• Potentiation of the Cytotoxicity of Chloroethylnitrosourea by O^6-Arylmethylguanines
• Demethylation of O^6-Methylguanine in DNA by O^6-Methylguanine-DNA Methyltransferase : Synthesis and Characterization of O^6,9-Dimethylguanine Coordinated with cis-Platin at the N7-Position
• Inhibitory Effect of Fatty Acids on 8-Hydroxydeoxyguanosine Formation in Calf Thymus DNA Treated with Bleomycin-Fe (II)
• Detection of 8-Hydroxy-2'-deoxyguanosine in Deoxyribonucleic Acid by the ^P-Postlabeling Method
• Some Cytotoxicological Aspects of Ethyl and Fluoroethyl Alkanesulfonates in Escherichia coli : Role of Fluorine Substitution
• Lignified Materials as a Potential Medicinal Resource. IV. Dehydrogenation Polymers of Some Phenylpropenoids and Their Capacity to Stimulate Polymorphonuclear Cell Iodination
• Formation of O^6,7-Dimethylguanine Residues in Calf Thymus Deoxyribonucleic Acid Treated with Carcinogenic N-Methyl-N-nitrosourea in Vitro
• Singlet Oxygen Takes Part in 8-Hydroxydeoxyguanosine Formation in Deoxyribonucleic Acid Treated with the Horseradish Peroxidase-H_2O_2 System
• LIGNIFIED NATURAL PRODUCTS AS POTENTIAL MEDICAL RESOURCES. : I POTENTIATION OF HEMOLYTIC PLAQUE-FORMING CELL PRODUCTION IN MICE
• Enhanced Cytotoxicity in Simultaneous and Sequential Drug-Heat Treatments of Cultured Chinese Hamster V79 Cells
• Deoxyribonucleic Acid (DNA) Damage Induced by Bleomycin-Fe(II) in Vitro : Formation of 8-Hydroxyguanine Residues in DNA
• DEPRIVATION OF THE MUTAGENIC PROPERTY OF QUINOLINE : INHIBITION OF MUTAGENIC METABOLISM BY FLUORINE SUBSTITUTION
• Potentiation of the Cytotoxic Activity of Anti-cancer Drugs against Cultured L1210 Cells by Bacillus thuringiensis subsp. israelensis Toxin
• Cytotoxicity of Fluorine-Containing Alkyl Alkanesulfonates to Cultured Leukemia L1210 Cells
• SYNERGISTIC EFFECT OF GLYCEROL ON CYTOTOXICITY OF BLEOMYCIN IN CULTURED CHINESE HAMSTER V79 CELLS
• Spontaneous and Enzymatic Activations of Carcinogenic N-Butyl-N',N'-dimethyl-N-nitrosourea(Biological)
• Studies on Chemical Carcinogens and Mutagens. XL. : Chemoselectivity of Acylating Agents toward Aniline in Aqueous Medium
• SYNTHESIS OF 7-AMINOGUANOSINE AND ITS CONVERSION TO 8-SUBSTITUTED DERIVATIVES
• Studies on Chemical Carcinogens and Mutagens. XXXVII. : A Simple Method to Predict Ultimate Structures of Chemical Mutagens, and Probably Carcinogens
• Detection of 8-Hydroxy-2'-deoxyguanosine in Deoxyribonucleic Acid by the ^P-Postlabeling Method
• Spontaneous and Enzymatic Activations of Carcinogenic N-Butyl-N',N'-dimethyl-N-nitrosourea(Biological)
• Detection of 8-Hydroxy-2'-deoxyguanosine in Deoxyribonucleic Acid by the ^P-Postlabeling Method
• Spontaneous and Enzymatic Activations of Carcinogenic N-Butyl-N',N'-dimethyl-N-nitrosourea(Biological)
• 薬学100年
• Studies on Chemical Carcinogens. XVIII. Acetylation of Carcinogenic 4-(N-Hydroxy-N-methylamino) quinoline 1-Oxide
• 薬学教育モデルカリキュラム作成に当っての考え方 : 薬学教育、薬剤師教育に関する基本姿勢
• The Structure of Nobilonine. The Second Alkaloid from Dendrobium nobile
• The Structure of Dendrobine
• Voltammetric and Spectroscopic Studies on the Carcinogen 4-(Hydroxyamino)quinoline N-Oxide and Its Analogues(Physical,Chemical)
• 有機化学的にみた発癌因子--物質の化学構造と発癌性
• 化学発癌物質とそのメカニズム
• Metabolism of Mutagenicity-Deprived 3-Fluoroquinoline : Comparison with Mutagenic Quinoline
• Effect of Metal Ions on Transcription of the ada Gene Which Encodes O^6-Methylguanine-DNA Methyltransferase of Escherichia coli
• Studies on Chemical Carcinogens. XXIV. mutagenic Potency of Alkylated 4-Nitroquinoline 1-Oxides : Its Dependence on the Rate of Metabolic Activation
• METABOLITES OF QUINOLINE, A HEPATOCARCINOGEN, IN A SUBCELLULAR MICROSOMAL SYSTEM
• Studies on Chemical Carcinogens. XXI. Quantitative Structure-Mutagenicity Relationship among Substituted Styrene Oxides
• Studies on Chemical Carcinogens. XX. Inhibitory Effect of Alkyl Isocyanates and Isothiocyanates on Mutagenesis in E. coli by Ultraviolet Radiation
• On the Relationship between C-13 Nuclear Magnetic Resonance Chemical Shift and Stability of Molecule in Methyl-Substituted N, N-Dimethylpiperidinium Salts
• Radical Methylation and Radical Hydroxymethylation of N-Substituted Quinoline Derivatives
• Studies on Hydrogen Exchange. XIV. Selective Hydrogen-Deuterium Exchange in Aliphatic Amines and Amino Acids catalyzed by Platinum
• Chemical Structure of QA_, One of the Covalently Bound Adducts of Carcinogenic 4-Nitroquinoline 1-Oxide with Nucleic Acid Bases of Cellular Nucleic Acids
• Studies on Chemical Alterations of Nucleic Acids and Their Components. X. syntheses and Reactivties of 3-Aminopyrimidine Nucleosides
• Selective Substitution Reactions of Quinoline Derivatives by Redox Systems Nucleophilic Character of Hydroxyalkyl Radicals
• 重水素標識化合物 (安定同位体の医・薬学,生物学への応用) -- (安定同位元素標識化合物)
• Studies on Chemical Alterations of Nucleic Acids and Their Components. VIII. Alkaline Rearrangement of 1-Aminoadenosine to 5-Amino-1-β-D-ribofuranosyl-4-(1,2,4-triazol-3-yl) imidazole
• Solvent-and Concentration-Dependent Shifts in Proton Magnetic Resonance of Quaternary Ammonium Salts
• Direct C-Amination of Guanosine with Hydroxylamine-O-Sulfonic Acid. Simplest Model Reaction possibly involved in DNA Damage leading to Carcinogenesis by N-Arylhydroxylamines
• Application of NMR to Stereochemistry. (I). The Spatial Interaction Effect of the Hydroxyl Group to Methyl Resonance.(53)
• 抗生物質の効果比較のための新しい手法と ED_ との相関性について
• Proton and Carbon-13 Nuclear Magnetic Resonance Chemical Shift Data for Nitroquinolines and Their N-Oxides
• Studies on Chemical Carcinogens and Mutagens. XXVI. Chemical Properties and Mutagenicity of Alkyl Alkanesulfonates on Salmonella typhimurium TA100
• Studies on Chemical Carcinogens and Mutagens. XXV. Chemoselectivity of Alkyl Sulfonates toward 4-(p-Nitrobenzyl) pyridine (NBP) in Phosphate Buffer
• Studies on Chemical Carcinogens and Mutagens. XXXII. Chemoselectivity of Alkylating Agents toward Pyridine in Aqueous Media-A Simple Procedure for Evaluation of Swain-Scott's Substrate Constants
• 学会誌のあり方について
• 薬学会賞受賞首藤紘一氏の業績
• 日本薬学会奨励賞受賞遠藤泰之氏の業績
• 薬剤師職能, 薬学教育を議論するために必要な認識
• 自然科学者としての一つの姿勢 : 良し悪しは別にして
• Lignified Materials as Potential Medicinal Resources.III. : Diversity of Biological Activity and Possible Molecular Species Involved
• 反応の律速因子の解明と制御(有機化学と生物の新しい接点を求めて)
• Studies on Chemical Carcinogens and Mutagens. XXXIII. : Mutation Frequencies Induced by Combinations of Methylating and/or Ethylating Mutagens
• 公開講座を語る
• Studies on Chemical Carcinogens. XXIII. A Simple Method for Characterization of the Alkylating Ability of Compounds by using 4-(p-Nitrobenzyl) pyridine
• Synthesis and Antitumor Effect of New Biological Alkylating Agents,Isethionic Acid Esters
• 学部教育では基礎学を, 薬剤師教育は修士課程で(薬学における有機化学教育のあり方)
• Alkaloids of Root-bark of Orixa japonica THUNB. XII. Nuclear Magnetic Resonance Study of N-Methylorixidinine, N-Methylisoorixidinine, and N-Methylorixidine.
• Studies on Chemical Carcinogens and Mutagens. XXXVI. : Apparent Activation Energy for Mutagenic Modification Induced in E. coli by Alkylating Agents. Estimation from Mutation Frequency
• Studies on Chemical Carcinogens and Mutagens. XXXV. : Standardization of Mutagenic Capacities of Several Common Alkylating Agents Based on the Concentration-Time Integrated Dose
• Application of Nuclear Magnetic Resonance to Stereochemistry. II. Determination of the Conformation of Hydroxyl Groups by Nuclear Magnetic Resonance ; Androst-4-en-3-one and Pregn-4-en-3-one Series.

もっと見る 閉じる

スポンサーリンク