Effect of DL-α-Tocopherol (Vitamin E) on the Differentiation of Mouse Myeloid Leukemia Cell

スポンサーリンク

概要

• 論文の詳細を見る

• The effect of DL-α-tocopherol on the differentiation of the mouse myeloid leukemia cell line (M1) was investigated using fluorometry. The reliability of the fluorometric determination was verified by the mutual overlapping of the curves of disappearance of the radioactivity recovered as α-tocopherol and the loss of its fluorescence. α-Tocopherol solubilized into the culture medium was relatively stable (t1/2=147-168hr). Incorporation of α-tocopherol into M 1 cells was time and dosedependent. Proliferation of M 1 cells was never inhibited, but was slightly enhanced by treatment with α-tocopherol. α-Tocopherol caused a twofold increase in acid-phosphatase activity and slightly inhibited both the spontaneous and dexamethasone-induced differentiation with respect to adhesion on glass and cell surface-rosette formation. α-Tocopherol also induced morphological change, making the shape of M 1 cells rounder.

• 財団法人 学会誌刊行センターの論文

著者

• 坂上 宏

  Department of Dental Pharmacology

• 須田 立雄

  Department of Biochemistry, School of Dentisry, Tokyo Medical and Dental University

• 坂上 宏

  1st Department Of Biochemistry School Of Medicine Showa University

• 阿部 悦子

  Department of Biochemistry, Showa University Dental School

• 浅香 一美

  Department of Biochemistry, School of Medicine

• 宮浦 千里

  Department of Biochemistry, School of Dentistry

• 紺野 邦夫

  Department of Biochemistry, School of Medicine

• 須田 立雄

  Department of Biochemistry, School of Dentistry

• 阿部 悦子

  Department of Biochemistry, School of Dentistry

• 坂上 宏

  Department of Biochemistry, School of Medicine

関連論文

• LIGNIFIED MATERIALS AS MEDICINAL RESOURCES. VI. ANTI-HIV ACTIVITY OF DEHYDROGENATION POLYMER OF p-COUMARIC ACID, A SYNTHETIC LIGNIN, IN A QUASI-IN-VIVO ASSAY SYSTEM AS AN INTERMEDIARY STEP TO CLINICAL TRIALS
• Lignified Materials as Medicinal Resources. V. Anti-HIV (Human Immunodeficiency Virus) Activity of Some Synthetic Lignins)
• クロロゲン酸で誘導される細胞毒性の塩化コバルトによる阻害
• クロロゲン酸によるヒト口腔癌細胞のアポトーシスの誘導
• クロロゲン酸と抗酸化剤との相互作用
• Lignified Materials as a Potential Medicinal Resource. IV. Dehydrogenation Polymers of Some Phenylpropenoids and Their Capacity to Stimulate Polymorphonuclear Cell Iodination
• LIGNIFIED NATURAL PRODUCTS AS POTENTIAL MEDICAL RESOURCES. : I POTENTIATION OF HEMOLYTIC PLAQUE-FORMING CELL PRODUCTION IN MICE
• Hydroboration of Steroidal-1,5-dien-3β-ols : A General Procedure for the Introduction of a Hydroxyl Group at 1α-Position of the 3-Oxygenated Steroids
• Synthesis of 25-Hydroxy-24-oxovitamin D_3,A New Metabolite of Vitamin D_3
• Lignified Materials as Potential Medicinal Resources.III. : Diversity of Biological Activity and Possible Molecular Species Involved
• EFFECTS OF VITAMIN D ON THE CHANGE OF CYCLIC NUCLEOTIDES AND DEOXYRIBONUCLEIC ACID CONTENTS IN RAT CALVARIA
• AN ASSAY METHOD FOR SEPARATELY MEASURING METABOLITES OF VITAMIN D3 AND THOSE PRESUMED TO BE DERIVED FROM VITAMIN D2
• Effect of DL-α-Tocopherol (Vitamin E) on the Differentiation of Mouse Myeloid Leukemia Cell
• Regulation and Its Refractoriness of 25-Hydroxyvitamin D3 Metabolism in Vitamin D Deficiency

もっと見る 閉じる

スポンサーリンク