Studies on Hydrogen Exchange. XII. Reaction Mechanism for Hydrogen Exchange of C-8 Hydrogen of Purine Ribosides

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概要

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• The reaction mechanism for the hydrogen exchange of C-8 hydrogens of purine ribosides was discussed on the basis of the pD-rate profiles and the effect of 6-substituents on the rate. It was shown that the rate depended on concentrations of the purine and D_2O and that the observed second-order rate constant was expressed as k_<OD>-K_<D_2O>/Ka (N_7) where k_<OD>-was the rate constant for hydrogen exchange of N_7-protonated purines by attack with the OD-, K_<D_2O> was the dissociation constant of D_2O, and Ka (N_7) was the dissociation constant of N_7-protonated purines.

• 公益社団法人日本薬学会の論文
• 1971-08-25

著者

• 川添 豊

  National Cancer Center Research Institute

• 前田 満和

  National Cancer Center Research Institute

• 実吉 峯郎

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 実吉 峯郎

  National Cancer Center Research Institute

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