Studies on Chemical Carcinogens. VI. Reductions of 3-and 8-Substituted 4-Nitroquinoline 1-Oxides
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Reductions of 3-and 8-substituted 4-nitroquinoline 1-oxides with H_2/Pd-C_3 NaBH_4,and phenylhydrazine were examined. These compounds were proved to be easily deoxygenated to produce the corresponding 4-hydroxyaminoquinolines in contrast to the fact that many other substituted 4-nitroquinoline 1-oxides were reduced to 4-hydroxyaminoquinoline 1-oxides under the same reduction conditions. These reductive behaviors were discussed in connection with the polarographic reduction potentials and the carcinogenic activity of these compounds.
- 公益社団法人日本薬学会の論文
- 1968-05-25
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