Synthesis and Reaction of 3-Fluoro-4-nitroquinoline 1-Oxide
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概要
- 論文の詳細を見る
3-Fluoroquinoline 1-oxide, which was prepared through the Schiemann reaction of 3-aminoquinoline, followed by N-oxygenation, was nitrated to 3-fluoro-4-nitroquinoline 1-oxide. The fluorine atom of this compound was replaced with nucleophiles such as OR- or NR_2-containing compounds in neutral or alkaline media to afford 3-substituted 4-nitroquinoline 1-oxide derivatives. The reaction with aqueous hydrogen chloride brought about the replacement of the nitro group to give 3-fluoro-4-chloroquinoline 1-xoide.
- 公益社団法人日本薬学会の論文
- 1968-09-25
著者
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川添 豊
National Cancer Center Research Institute
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実吉 峯郎
Faculty Of Pharmaceutical Sciences Hokkaido University
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実吉 峯郎
National Cancer Center Research Institute
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荒木 美佐子
National Cancer Center Research Institute
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原田 晴江
National Cancer Center Research Institute
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