Synthetic Nucleosides and Nucleotides. VIII. Direct Synthesis of the 5'-Phosphate of 4-Thiouridine, 6-Thioinosine and 6-Thioguanosine from the Corresponding Oxy Nucleotide via Thiation Procedure
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概要
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Direct and simple methods for the preparations of 4-thiouridine 5'-phosphate (IVa), 6-thioinosine 5'-phosphate (IVb) and 6-thioguanosine 5'-phosphate (IVc) from the corresponding oxy-nucleotides are described. The 5'-ribonucleotides are converted to their 2', 3'-di-O-acetylated derivatives by a conventional acetylation procedure, followed by thiation with phosphorus pentasulfide to give crude thiated products. For the selective desulfurization, the crude products are treated with dicyclohexylcarbodiimide, followed by alkaline deacylation to give the desired "thio" nucleotides.
- 公益社団法人日本薬学会の論文
- 1971-03-25
著者
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実吉 峯郎
Faculty Of Pharmaceutical Sciences Hokkaido University
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実吉 峯郎
National Cancer Center Research Institute
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