The Correlation between the Antitumor Activities and Chemical Structures of Thiocyanato Derivatives of Purines and Their Ribonucleosides
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概要
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The effect of 14 thiocyanato derivatives of purines and their ribonucleosides were compared with the effects of 6-purinethiol and 2-amino-6-purinethiol against transplanted sarcoma (NF-Sarcoma) in mice and the correlation was noted between antitumor activities and substituting position of thiocyanato group and other substituent groups on the purine ring. 6-Thiocyanatopurine, 2-amino-6-thiocyanatopurines and their ribonucleosides were demonstrated as the most active of the thiocyanato derivatives.
- 公益社団法人日本薬学会の論文
- 1968-03-25
著者
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福岡 文子
National Cancer Center Research Institute
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前田 満和
National Cancer Center Research Institute
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実吉 峯郎
Faculty Of Pharmaceutical Sciences Hokkaido University
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実吉 峯郎
National Cancer Center Research Institute
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徳善 玲子
National Cancer Center Research Institute
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