Synthetic Nucleosides and Nucleotides. IX. Synthesis of 2', 5'- and 3', 5'-Di-O-tritylcytidine and the Related Compounds via Thiation
スポンサーリンク
概要
- 論文の詳細を見る
Thiation of the 2', 5'-di-O-trityl-3'-O-acetyluridine or 3', 5'-di-O-trityl-2'-O-acetyluridine with phosphorus pentasulfide in refluxing toluene containing 20-30% pyridine afforded corresponding"4-thio"derivative in good yield. These "4-thio" derivatives were converted to the cytidine counterparts by the reaction with methanolic ammonia. 2', 5'-Di-O-trityl-3'-O-methanesulfonyluridine was also converted to cytidine derivative by similar manner. In addition, phosphorylation and dinucleoside monophosphate synthesis using titled compounds were described.
- 公益社団法人日本薬学会の論文
- 1975-05-25
著者
-
実吉 峯郎
Faculty Of Pharmaceutical Sciences Hokkaido University
-
実吉 峯郎
National Cancer Center Research Institute
関連論文
- Synthetic Nucleosides and Nucleotides. XVI. Synthesis and Biological Evaluations of a Series of 1-β-D-Arabinofuranosylcytosine 5'-Alkyl or Arylphosphates
- Mode of Action of 5-Fluorocytidine and 5-Fluoro-2'-deoxycytidine in L5178Y Cells in Vitro
- Synthetic Nucleosides and Nucleotides. XIII. Stannic Chloride Catalyzed Ribosylation of Several 6-Substituted Purines
- Synthetic Nucleosides and Nucleotides. I. On Synthesis and Properties of Several Thiocyanato Derivatives of Purines and Their Ribonucleosides.
- Biological Photochemistry. I. The Correlation between the Photodynamical Behaviors and the Chemical Structures of Nucleic Acid-bases, Nucleosides, and Related Compounds in the Presence of Methylene-blue
- Resistance of Cyclocytidine to Cytidine Deaminase
- Synthetic Nucleosides and Nucleotides. XVIII. Synthesis and Cytostatic Activity of 5-Fluoropyrimidine Nucleosides of 3-Amino-3-deoxy-β-D-ribofuranose and Related Compounds
- Synthetic Nucleosides and Nucleotides. XIX. Synthesis of 3'-Deoxycytidine 5'-Triphosphate and Related 3'-Deoxy-ribonucleotides from Cordycepin'
- Studies on Hydrogen Exchange. XII. Reaction Mechanism for Hydrogen Exchange of C-8 Hydrogen of Purine Ribosides
- The Correlation between the Antitumor Activities and Chemical Structures of Thiocyanato Derivatives of Purines and Their Ribonucleosides
- Synthetic Nucleosides and Nucleotides. XXVII. Selective Inhibition of Deoxyribonucleic Acid Polymerase α by 1-β-D-Arabinofuranosyl-5-styryluracil 5'-Triphosphates and Related Nucleotides : Influence of Hydrophobic and Steric Factors on the Inhibitory Acti
- Synthetic Nucleosides and Nucleotides. XI. : Facile Synthesis and Antitumor Activities of Various 5-Fluoropyrimidine Nucleosides
- Synthetic Nucleosides and Nucleotides. XXVIII. : Synthesis of 5-Alkylcytidines from 5-Alkylbarbituric Acids
- Synthetic Nucleosides and Nucleotides. XV. 5-Dimethylamino-2-oxidoisoquinolin-1-yl Diazomethane : A Novel Water-soluble Fluorescent Labelling Agent for Nucleotides
- Synthetic Nucleosides and Nucleotides. IX. Synthesis of 2', 5'- and 3', 5'-Di-O-tritylcytidine and the Related Compounds via Thiation
- Synthetic Nucleosides and Nucleotides. VIII. Direct Synthesis of the 5'-Phosphate of 4-Thiouridine, 6-Thioinosine and 6-Thioguanosine from the Corresponding Oxy Nucleotide via Thiation Procedure
- Synthetic Nucleotides. VII. A Direct Replacement of 6-Thiol Group of 6-Thioinosine with Hydrazine Hydrate
- Synthetic Nucleosides and Nucleotides. VI. On the Several Routes for the Syntheses of 4-Thiouridylic Acid Homologues
- Synthesis and Reaction of 3-Fluoro-4-nitroquinoline 1-Oxide
- Synthetic Nucleosides and Nucleotides. III. On the Syntheses of Several 2,6,8-Trisubstituted Purine Ribonucleosides
- Direct Thiation of Uridine 5'-Phosphate
- Syntheses and Properties of Several 4-Alkyl-or Arylsulfonylquinoline 1-Oxides