SYNTHESIS OF A HEPTACONTAPEPTIDE CORRESPONDING TO THE ENTIRE AMINO ACID SEQUENCE OF EGLIN C

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概要

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• A heptacontapeptide corresponding to the entire amino acid sequence of eglin c was synthesized by the conventional solution method using a minimal protecting method. The synthetic eglin c exhibited a symmetrical single peak on HPLC at the same retention time as an authetic eglin c, and had the same inhibitory activity against human leukocyte elastase, cathepsin G and α-chymotrypsin (Ki = 6.0 x 10^<-9> M, 5.5 x 10^<-9>M and 2.5 x 10^<-9> M, respectively) as N^α-acetyl-eglin c synthesized genetically (Ki = 5.1 x 10^<-9> M, 1.5 x 10^<-8> M and 2.2 x 10^<-9> M, respectively).

• 社団法人日本薬学会の論文
• 1990-10-25

著者

• 岡田 芳男

  Faculty of Pharmaceutical Sciences Kobe-Gakuin University

• 永松 陽子

  Faculty Of Nutrition Kobe-gakuin University

• 坪井 諭志

  Faculty of Pharmaceutical Sciences Kobe-Gakuin University

• 山本 順一郎

  Faculty of Nutrition, Kobe-Gakuin University

• 坪井 論志

  Faculty of pharmaceutical Sciences

• 山本 順一郎

  Faculty Of Nutrition Kobe-gakuin University

関連論文

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