Synthesis of Tripeptide Chloromethyl Ketones and Examination of Their Inhibitory Effects on Plasmin and Plasma Kallikrein

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概要

• 論文の詳細を見る

• With the aim of obtaining selective synthetic inhibitors of plasmin and plasma kallikrein, D-Ile-Phe-Lys-CH_2Cl, Ile-Phe-Lys-CH_2Cl, D-Ile-Phe-Arg-CH_2Cl and Ile-Phe-Arg-CH_2Cl were synthesized and their inhibitory activity against plasmin, plasma kallikrein and other trypsin-like serine proteinases was examined. Among them, D-Ile-Phe-Arg-CH_2Cl exhibited a highly selective inhibitory activity against plasma kallikrein, yet D-Ile-Phe-Lys-CH_2Cl exhibited nearly the same order of inhibitory activity against plasmin as well as plasma kallikren.

• 社団法人日本薬学会の論文
• 1989-11-25

著者

• 岡田 芳男

  Faculty of Pharmaceutical Sciences Kobe-Gakuin University

• 津田 裕子

  Faculty of Pharmaceutical Sciences

• 手納 直規

  Faculty of Pharmaceutical Sciences

• 津田 裕子

  神戸学院大学薬学部薬品化学

• 岡田 芳男

  神戸学院大学 薬学部

• 和中 敬子

  Kobe Research Projects on Thrombosis and Haemostasis

• 岡本 歌子

  Kobe Research Projects on Thrombosis and Haemostasis

• 岡本 彰祐

  Kobe Research Projects on Thrombosis and Haemostasis

• 土方-奥宮 明子

  School of Allied Medical Sciences, Kobe University

• 内藤 威敏

  Life Science Research Lab., Showa Denko Co., Ltd.,

• 手納 直規

  Faculty Of Pharmaceutical Sciences Kobe-gakuin University

• 内藤 威敏

  Kobe Research Projects On Thrombosis And Haemostasis Saiseikai Hyogo Hospital

• 土方-奥宮 明子

  School Of Allied Medical Sciences Kobe University

• 岡本 歌子

  血栓止血研究神戸プロジェクト

• 坊垣 美也子

  Kobe Research Projects on Thrombosis and Haemostasis, Saiseikai Hospital

• 岡本 彰祐

  血栓止血研究神戸プロジェクト

• 坊垣 美也子

  Kobe Research Projects On Thrombosis And Haemostasis Saiseikai Hospital

関連論文

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