SIGNIFICANT EFFECTS OF SYNTHETIC GLN-VAL-VAL-ALA-GLY AND ITS DERIVATIVES, COMMON SEQUENCES OF THIOL PROTEINASE INHIBITORS, ON THIOL PROTEINASE
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概要
- 論文の詳細を見る
The Gln-Val-Val-Ala-Gly sequence occurs frequently in several thiol proteinase inhibitors, suggesting that this conserved sequence may be one of the reactive sites in the inhibitors. In order to study the effects of the sequence on thiol proteinases, we synthesized H-Gln-Val-Val-Ala-Gly-OH (VI) and its related peptide derivatives by the conventional solution method and examined their effects on the enzymatic activity of papain. We found that Z-Gln-Val-Val-Ala-Gly-OMe (IV) not only inhibits papain but also protects it from T-kininogen, which is one of thiol proteinase inhibitors. Apparently this peptide (IV) binds with some part of papain in competition with T-kininogen.
- 公益社団法人日本薬学会の論文
- 1985-11-25
著者
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岡本 博
Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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伊藤 徳夫
Department of Pharmacology, Faculty of Pharmaceutical Sciences
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伊藤 徳夫
Department Of Pharmacology Faculty Of Pharmaceutical Sciences
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岡田 芳男
Department of Dermatology
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手納 直規
Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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手納 直規
Departments of Medicinal Chemistry
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伊藤 徳夫
Pharmacology
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岡本 博
Pharmacology
関連論文
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- Amino Acids and Peptides. XX. : Inhibition of Papain by Succinyl-Gln-Val-Val-Ala-p-Nitroanilide, a Common Sequence of Endogenous Thiol Proteinase Inhibitors
- SIGNIFICANT EFFECTS OF SYNTHETIC GLN-VAL-VAL-ALA-GLY AND ITS DERIVATIVES, COMMON SEQUENCES OF THIOL PROTEINASE INHIBITORS, ON THIOL PROTEINASE