Reaction of Tosylmethyl Isocyanide with Methyl 3-Substituted Propiolates as Acetylenic Michael Acceptors
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概要
- 論文の詳細を見る
The reaction of tosylmethyl isocyanide (7) with methyl propiolate (14a), dimethyl acetylenedicarboxylate (14b), methyl 3-(2-furoyl) propiolate (14c), and methyl 3-benzoylpropiolate (14d) in the presence of an equimolar amount of base at room temperature gave the corresponding 1 : 2 adducts, i.e., methyl 3-(1-pyrrolyl) acrylate derivatives (16a, 16b, 16c, and 16d, respectively) as final products. The temperature dependence of the reaction made it possible to isolate the pyrroles (15a and 15b), postulated as intermediates of the reaction, at low temperature.
- 社団法人日本薬学会の論文
- 1979-11-25
著者
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佐々木 秀明
Faculty of Pharmaceutical Sciences
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北川 徳治郎
Faculty of Pharmaceutical Sciences
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佐々木 秀明
Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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北川 徳治郎
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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西海枝 東雄
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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西海枝 東雄
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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