Preparation of Optically Active 2-(Trifluoromethyl)alkan-1-ols by Catalytic Asymmetric Hydrogenation
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概要
- 論文の詳細を見る
The hydrogenation of (E)-2-(trifluoromethyl)alk-2-en-1-ols catalyzed by Ru-2,2'-bis(diphynylphosphino)-1,1'-binaphthyl (Ru-BINAP) and Rh-BINAP was carried out with good enantiomeric excess (71-83% ee). Ru-BINAP-catalyzed hydrogenation converted 2-(trifluoromethyl)acrylic acid to the corresponding saturated acid whose esterification and reduction provided optically active 2-(trifluoromethyl)propan-1-ol in 80% ee.
- 公益社団法人日本薬学会の論文
- 1996-03-15
著者
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NAGAI Takabumi
MEC Laboratory, Daikin Industries, Ltd.
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Nagai Takabumi
Mec Laboratory Daikin Industries Ltd.
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Yasui Koichiro
Molecular Gastroenterology And Hepatology Kyoto Prefectural University Of Medicine Graduate School O
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Yasui Kohichiroh
Molecular Gastroenterology And Hepatology Kyoto Prefectural University Of Medicine Graduate School O
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Kobayashi Yoshiharu
Tokyo University of Pharmacy and Life Science
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KUROKI Yoshichika
MEC Laboratory, Daikin Industries, Ltd.
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ISEKI Katsuhiko
MEC Laboratory, Daikin Industries, Ltd.
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KOBAYASHI Yoshiro
MEC Laboratory, Daikin Industries, Ltd.
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Iseki K
Mec Laboratory Daikin Industries Ltd.
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Kuroki Yoshichika
Mec Laboratory Daikin Industries Ltd.
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Yoshida Kyotaro
Dep. Of Medical Biochemistry Kobe Pharmaceutical Univ.
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KUROKI Yoshichika
MEC Laboratory, Daikin Industries, Ltd.,
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