Effect of a Kampo Preparation, Byakkokaninjinto, on Pharmacokinetics of Ciprofloxacin and Tetracycline
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概要
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The effect on the bioavailability of the antimicrobial agents (ciprofloxacin and tetracycline), which are well known to form chelates with cationic metals such as calcium, was evaluated in 20 healthy male volunteers according to an open, random crossover fashion using a Kampo preparation, byakkokaninjinto (TJ-34) which contains various cationic metals including calcium. Each subject received a single oral dose of tetracycline (250 mg) alone or ciprofloxacin (200 mg) alone along with a single coadministration of one pack (3 g) of the Kampo preparation, at one-week intervals. Concentrations of the drugs in plasma and urine were analyzed by HPLC. Concomitant administration of the Kampo preparation significantly decreased the peak plasma concentration (Cmax) and area under the plasma concentration–time curves (AUC), but not time to reach Cmax (Tmax), of ciprofloxacin and tetracycline. However, the decrease in bioavailability of ciprofloxacin was slight (15%) compared with that of tetracycline (30%). The Kampo preparation significantly decreased the urinary recovery of tetracycline, but not ciprofloxacin, and it had no effect on the renal clearance of either ciprofloxacin or tetracycline. These results indicate that the Kampo preparation tested in this study reduces the extent of bioavailability of ciprofloxacin and tetracycline, but not renal excretion, by decreasing the gastrointestinal absorption due to the formation of insoluble chelates with calcium. We recommend that the dose timing of the Kampo preparation should be carefully controlled to avoid therapeutic failure especially for patients receiving the treatment with tetracycline.
著者
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Ohnishi Masafumi
Department Of Hospital Pharmacy Aichi Medical University School Of Medicine
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Abe Fumie
Department Of Mechanical Engineering Faculty Of Engineering Science Osaka University
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Nadai Masayuki
Faculty Of Pharmacy Meijo University
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Kato Miki
Department Of Pharmacy And Pharmacokinetics Aichi Medical University School Of Medicine
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Haniuda Masayuki
Department Of Chest Surgery Aichi Medical University
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Hasegawa Takaaki
Department Of Hospital Pharmacy Nagoya University School Of Medicine
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KATOH Miki
Faculty of Pharmacy, Meijo University
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Saito Hiroko
Department Of Biological Mechanisms And Functions Graduate School Of Bioagricultural Sciences Nagoya
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Kurono Shunsuke
Department Of Hospital Pharmacy Aichi Medical University
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Hitoshi Kotaro
Faculty of Pharmacy, Meijo University
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Nadai Masayuki
Faculty Of Pharmaceutical Sciences Meijo University
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Hitoshi Kotaro
Department Of Pharmaceutics Faculty Of Pharmacy Meijo University
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Kurono Shunsuke
Department of Pharmacy and Pharmacokinetics, Aichi Medical University School of Medicine
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Ohnishi Masafumi
Department of Pharmacy and Pharmacokinetics, Aichi Medical University School of Medicine
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HASEGAWA Takaaki
Department of Bacteriology, Nagoya University School of Medicine
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