Identification of another surface protein antigen I/II gene, paaB, and a putative transcriptional regulator gene, par, from Streptococcus cricetus
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概要
- 論文の詳細を見る
The flanking region of the antigen I/II gene, paaA, in Streptococcus cricetus was examined using the gene-walking technique. In the region downstream of the paaA gene, another antigen I/II gene designated as paaB was found. The paaB gene was disrupted at the alanine-rich region (A region) by a novel insertion sequence element, ISScr1. ISScr1 is a member of the IS982 family and is composed of a 962-bp sequence and duplicated target DNA (the sequence 5-TAGCTAAAT-3) resulting from its insertion. To clarify the structural divergence of the two antigen I/II proteins (PAaA and PAaB), computational analysis of the paaB gene was performed and the two structures were compared. The amino acid sequence homology indicated that PAaB resembled PAaA, but the middle region showed little similarity to that of PAaA. Phylogenetic analysis showed that PAaB was better classified in a major group with S. mutans PAc and S. gordonii SspA and SspB than with PAaA. The transcriptional expression of paaA and paaB was demonstrated by reverse transcription (RT)-PCR. In the region upstream of the paaA gene, three genes homologous to the genes located in the region upstream of the S. sobrinus antigen I/II gene (pag) were found. Of the three genes, ORF3 showed homology to the par gene encoding a transcriptional repressor for the pag gene in S. sobrinus. Therefore, ORF3 was designated the par gene of S. cricetus. Southern hybridization revealed that the par gene of S. cricetus was not found in other oral streptococci examined in this study.
- 日本遺伝学会の論文
- 2004-06-25
著者
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KATO Hirohisa
Departments of Pediatrics, Kurume University School of Medicine
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SAITO Hiroko
Department of Pharmacy and Pharmacokinetics, Aichi Medical University School of Medicine
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MURAI Shigeo
Department of Pharmacology, School of Dentistry, Iwate Medical University
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Kato Hirohisa
Department Of Dental Pharmacology School Of Dentistry Iwate Medical University
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TAMURA Haruki
Department of Dental Pharmacology, School of Dentistry, Iwate Medical University
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YAMADA Arisa
Department of Dental Pharmacology, School of Dentistry, Iwate Medical University
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Yamada Arisa
Department Of Dental Pharmacology School Of Dentistry Iwate Medical University
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Murai Shigeo
Department Of Dental Pharmacology School Of Dentistry Iwate Medical University
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Tamura Haruki
Department Of Dental Pharmacology School Of Dentistry Iwate Medical University
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Saito Hiroko
Department Of Biological Mechanisms And Functions Graduate School Of Bioagricultural Sciences Nagoya
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Kato Hirohisa
Department Of Cardiovascular Medicine National Center For Child Health And Development
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Saito Hiroko
Department Of Dental Pharmacology School Of Dentistry Iwate Medical University
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YAMADA Arisa
Division of Bioregulatory Pharmacology, Department of Pharmacology, Iwate Medical University
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Kato Hirohisa
Division of Bioregulatory Pharmacology, Department of Pharmacology, Iwate Medical University
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