Aspergillus Osteomyelitis in a Child Who Has p67-phox-deficient Chronic Granulomatous Disease.
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概要
- 論文の詳細を見る
Here we describe Aspergillus osteomyelitis of the tibia in a 9-year-old boy who has an autosomal recessive form of chronic granulomatous disease (CGD). The patient showed a p67-phagocyte oxidase (phox) deficiency, which is rare type of CGD in Japan. The initial treatment which consisted of surgical debridement and antibiotic therapy with amphotericin B (AMPH), did not control the infection. Aspergillus fumigatus (A. fumigatus) pure isolated from drainage fluid and necrotic bone tissue demonstrated less susceptible to antifungal agents, including AMPH, fluconazole and flucytosine. Recombinant interferon gamma was then administrated, and it was effective in controlling the course of severe invasive aspergillosis. This report indicates the use of interferon gamma might be helpful in control for Aspergillus osteomyelitis of the tibia in a child with CGD demonstrated p67-phox deficiency refractory to conventional therapy with AMPH.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Tsumura Naoki
Department Of Pediatrics And Child Health Kurume University School Of Medicine
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Sakata Yasutaka
Department Of Pediatrics And Child Health Kurume University School Of Medicine
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Kato Hirohisa
Department Of Cardiovascular Medicine National Center For Child Health And Development
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Inoue Akio
Department Of Astronomy Faculty Of Science Kyoto University
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Oda Keiko
Department Of Neurosurgery Fukushima Medical University
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KATO HIROHISA
Departments of Pediatrics and Child Health, Kurume University School of Medicine
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AKASU YUKO
Departments of Pediatrics and Child Health, Kurume University School of Medicine
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YAMANE HIROMASA
Departments of Pediatrics and Child Health, Kurume University School of Medicine
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IKEZAWA SHIGERU
Departments of Pediatrics and Child Health, Kurume University School of Medicine
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HIRATA TOMOSHIGE
Departments of Pediatrics and Child Health, Kurume University School of Medicine
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SHIRAHAMA MASAHIRO
Departments of Orthopaedic surgery, Kurume University School of Medicine
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IKEZAWA SHIGERU
Department of Pediatrics and Child Health, Kurume University School of Medicine
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SHIRAHAMA MASAHIRO
Department of Orthopaedic Surgery, Kurume University School of Medicine
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