Placental Transport of Bile Acids: Analysis of Bile Acids in Maternal Serum and Urine, Umbilical Cord Blood, and Amniotic Fluid.
スポンサーリンク
概要
- 論文の詳細を見る
To investigate the role of placental transport of bile acids in fetal bile acid metabolism, such as with regard to synthesis of the unusual bile acids (1β-and 6α-hydroxylated and unsaturated bile acids), we measured the concentrations of bile acids in umbilical cord blood, amniotic fluid, maternal serum and maternal urine at delivery by means of gas chromatography-mass spectrometry. Serum and urine from healthy nonpregnant women were used as controls. We detected large amounts of unusual bile acids, especially hyocholic acid and 3β-hydroxy-Δ<SUP>5</SUP> bile acids, in amniotic fluid and umbilical cord blood. The concentration of total bile acids in maternal serum was less than that of control serum and umbilical cord blood, and the concentration of total bile acids in maternal urine was higher than that of control urine and amniotic fluid. In conclusion, the fetussynthesized large amounts of unusual bile acids, and these compounds were transported from fetus to mother by placental transfer. We suggest that pregnant women may excrete large amounts of bile acids into the urine to control serum concentration of bile acids in fetus.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
-
Kato Hirohisa
Department Of Pediatrics And Child Health Kurume University School Of Medicine
-
Maeda Kohji
Department Of Pediatrics And Child Health Kurume University School Of Medicine
-
Maeda Kohji
Department Of Bioscience Fukui Prefectural University
-
Kimura Akihiko
Department Of Anatomy School Of Medicine Toho University
-
Ushijima Kosuke
Department Of Pediatrics And Child Health Kurume University School Of Medicine
-
Yamashita Yasuhiro
Department Of Pediatrics And Child Health Kurume University School Of Medicine
-
Inokuchi Takahiro
Research Institute Of Medical Mass Spectrometry Kurume University School Of Medicine
-
Yamato Yasuhiko
Department Of Pediatrics And Child Health Kurume University School Of Medicine
-
Kato Hirohisa
Department Of Cardiovascular Medicine National Center For Child Health And Development
-
Nakashima Eisuke
Department Of Patholigy Kurume University School Of Medicine
-
Yamashita Yasuhiro
Department of Biotechnology, Faculty of Engineering, Kansai University
関連論文
- Analysis of tumor necrosis factor-α production and polymorphisms of the tumor necrosis factor-α gene in individuals with a history of Kawasaki disease
- The test of variables of attention (TOVA) is useful in the diagnosis of Japanese male children with attention deficit hyperactivity disorder
- Sleep disorder in Rett syndrome and melatonin treatment
- Cerebral oxygenation and hemodynamics during hyperventilation and sleep in patients with Rett syndrome
- Balo's concentric sclerosis in a 4-year-old Japanese infant
- Heat stroke-like episode in child caused by zonisamide
- 先天性胆汁酸代謝異常症の尿中胆汁酸分析依頼システム : 本邦における10年間の成績
- VASOACTIVE INTESTINAL POLYPEPTIDE AND CALBINDIN-D28K IMMUNOREACIVE NEURONS IN THE OLFACTORY BULB OF THE MUSK SHREW, SUNCUS MURINUS(Cell Biology and Morphology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- Guidelines for catheter intervention in coronary artery lesion in Kawasaki disease
- Tyrosinemia type I-like disease : A possible manifestation of 3-oxo-△^4-steroid 5β-reductase deficiency
- Determination of 3-oxo-Δ^4- and 3-oxo-Δ^-bile acids and related compounds in biological fluids of infants with cholestasis by gas chromatography-mass spectrometry
- Determination of fetal bile acids in biological fluids from neonates by gas chromatography-negative ion chemical ionization mass spectrometry
- Transcatheter Closure of Atrial Septal Defects With the Amplatzer Septal Occluder : A Japanese Clinical Trial
- Transcatheter Occlusion of Patent Ductus Arteriosus With a New Detachable Coil System(DuctOcclud) : a Multicenter Clinical Trial
- Balloon Angioplasty for Aortic Coarctation : Report of a Questionnaire Survey by the Japanese Pediatric Interventional Cardiology Committee
- -0478-TRANSVENOUS CATHETER OCCLUSION OF PATENT DUCTUS ARTERIOSUS WITH THE RASHKIND PDA OCCLUSION SYSTEM
- Liver regeneration after portal vein plus hepatic artery ligation performed heterochronously in rats
- Novel mutations in five Japanese patients with 3-methylcrotonyl-CoA carboxylase deficiency
- -0399- INTRAVASCULAR ULTRASOUND IMAGING IN CHILDREN AFTER KAWASAKI DISEASE : ASSESSMENT OF CORONARY & SYSTEMIC ARTERY, AND APPLICATION TO INTERVENTION.(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- Identification and Characterization of a Dextranase Gene of Streptococcus criceti
- Identification of another surface protein antigen I/II gene, paaB, and a putative transcriptional regulator gene, par, from Streptococcus cricetus
- Molecular Evolution of Human Echovirus 9 Isolated from Patients with Aseptic Meningitis in Northern Kyushu during the Summer of 1997
- Epidemiology of Helicobacter pylori infection in children : A serologic study of the Kyushu region in Japan
- Long-term Follow-up Results in Catheter Intervention for Kawasaki Disease : Quantitative Coronary Artery Angiography and Intravascular Ultrasound Imaging Study
- Quantitative assessment of severity of infants with ventricular septal defect by natriuretic peptides
- Catheter closure of moderate to large sized patent ductus arteriosus using the simultaneous double or triple coil technique
- Re-treatmemt for immune globulin-resistant Kawasaki disease : A comparative study of additional immune globulin and steroid pulse therapy
- Role of Apoptosis in the Closure of Neonatal Ductus Arteriosus
- Serial evaluation for myocardial performance in fetuses and neonates using a new Doppler index
- Progression of congenital heart disease in the prenatal period
- Coil Occlusion of Aortopulmonary Collateral Arteries in an Infant With Scimitar Syndrome
- Selective high dose gamma-globulin treatment in Kawasaki disease : Assessment of clinical aspects and cost effectiveness
- -0405- EVALUATION OF THE SEVERITY OF PULMONARY HYPERTENSION RELATED WITH CONGENITAL HEART DISEASE : CLINICAL EFFICACY OF INHALED NITRIC OXIDE CHALLENGE TEST(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- -0394- STENTING OF THE DUCTUS ARTERIOSUS IN NEWBORN PIGLETS : COMPARISON OF EXPERIMENTAL EFFICACY BETWEEN PALMATZ-SCHATZ AND GIANTURCO-ROUBIN STENTS(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- Evaluation of Pulmonary Arterial Pathology in Congenital Heart Disease : In Vitro Study Using Intravascular Ultrasound Imaging
- IMPROVEMENT OF LEFT VENTRICULAR PERFORMANCE AFTER MYOCARDIAL INFARCTION IN PATIENTS WITH KAWASAKI DISEASE
- MYOCARDIAL ISCHEMIA IN KAWASAKI DISEASE : EVALUATION BY DIPYRIDAMOLE STRESS THALLIUM-201(Tl-201)MYOCARDIAL IMAGING
- INTRAVASCULAR ULTRASOUND IMAGING OF CORONARY ARTERY IN CHILDREN AFTER KAWASAKI DISEASE:ASSESSMENT OF WALL MORPHOLOGY IN REGRESSED CORONARY ANEURYSMS AND ANGIOGRAPHICALLY NORMAL CORONARY ARTERY
- Mortality Among Persons with a History of Kawasaki Disease in Japan : Existence of Cardiac Sequelae Elevated the Mortality
- 川崎病既往者の死亡率 : 第3回目の追跡
- -0124-SUDDEN DEATH AFTER SURGERY IN PATIENTS WITH CONGENITAL HEART DISEASE
- MITRAL VALVE PROLAPSE SYNDROME (MVP) IN CHILDHOOD : CHANGE OF INCIDENCE AND CLINICAL MANIFESTATIONS BY AGE : Valvular Heart Disease : 53 Annual Scientific Meeting, Japanese Circulation Society
- TERM FOLLOW-UP OF CORONARY ARTERIAL LESIONS IN KAWASAKI DISEASE : SERIAL ANGIOGRAPHIC STUDY : Congenital Heart Disease, Kawasaki Disease : 53 Annual Scientific Meeting, Japanese Circulation Society
- FETAL AND NEONATAL TRANSITIONAL CIRCULATION : PULSED DOPPLER ECHOCARDIOGRAPHIC EVALUATION : Congenital Heart Disease, Kawasaki Disease : 53 Annual Scientific Meeting, Japanese Circulation Society
- LONG TERM OF EVALUATION OF HEMODYNAMIC FINDINGS AND MORPHOLOGIC CHANGES OF RIGHT VENTRICULAR OUTFLOW TRACT AFTER BALLOON PULMONARY VALVULOPLASTY : Congenital Heart Disease, Kawasaki Disease : 53 Annual Scientific Meeting, Japanese Circulation Society
- -156- INCIDENCE OF MITRAL VALVE PROLAPSE IN NEONATES, INFANTS AND CHILDREN : A TWODIMENSIONAL ECHOCARDIOGRAPHIC STUDY OF 2285 NORMAL SUBJECTS : Myocardial Infarction, Valvular Heart Disease : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTI
- Infective Endocarditis in Children : A Current Diagnostic Trend and the Embolic Complications : THE 10th CONFERENCE ON THE 10th CONFERENCE ON PREVENTION FOR RHEUMATIC FEVER AND RHEUMATIC HEART DISEASE
- DIAGNOSIS AND TREATMENT FOR FETUSES WITH CARDIAC PROBLEMS : Congenital Heart Disease, Kawasaki Disease : IV : 48 Annual Scientific Meeting, Japanese Circulation Society
- TWO-DIMENSIONAL ECHOCARDIOGRAPHY USING LINEAR SCANNER FOR CONGENITAL HEART DISEASE : EVALUATION FOR RIGHT VENTRICULAR STRUCTURE : Electrophysiology : 46th Annual Scientific Meeting, Japanese Circulation Society
- Severe brainstem compression by an unruptured giant vertebral aneurysm : An autopsy case
- Synthesis, Crystal Structure and Magnetic Properties of Iron Particles Encaged in Carbon Nanocapsules
- Magnetic Anisotropy of Co/Pt Multilayers Evaporated on NaCl(100) Substrates
- Magnetostatic Uniaxial Anisotropy in Metal Magnetic Tape
- Congenital toxoplasmosis complicated by central diabetes insipidus in an infant with Down syndrome
- Perinatal bile acid metabolism : bile acid analysis of meconium of preterm and full-term infants
- Acute severe hepatitis : Successful prevention of fulminant hepatic failure with early intensive medical therapy
- Two neonates with intussusception accompanying severe hypoxia
- Abnormally low ratio of cholic acid to chenodeoxycholic acid due to a deficiency of 3-oxo-Δ^4-steroid 5β-reductase
- Guidelines for care of pregnant women carrying hepatitis C virus and their infants
- Binding Affinity of Basic Amino Acids to the Surface of a Neutral Phospholipid Monolayer
- Evaluation of the Associate Constant of a Phospholipid-Ca^ Complex Using a Phospholipid Monolayer Adsorbed at an Aqueous | 1,2-dichloroethane Interface
- A possible mechanism of neonatal intrahepatic cholestasis caused by citrin deficiency
- FIBROMUSCULAR LAYER IN THE RESPIRATORY TRACT OF RED-BELLIED NEWT (CYNOPS PYRRHOGASTER)(Cell Biology and Morphology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- DISTRIBUTION OF NEE CELLS AND NEBS IN THE RESPIRATORY TRACT OF RED-BELLIED NEWT (CYNOPS PYRRHOGASTER)(Cell Biology and Morphology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- LOCALIZATION OF SEROTONIN-IMMUNOREACTIVE CELLS IN THE RESPIRATORY TRACT OF URODELA : THE TAILED AMPHIBIANS(Cell Biology and Morphology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- Gene expression of cytokines and growth factors in the lungs after paraquat administration in mice
- Voltammetric Study on the Transport of Ions or Various Hydrophobicity Types through Bilayer Lipid Membranes Composed of Various Lipids
- 潰瘍性大腸炎患児における血球浄化療法
- Helicobacter pylori seropositivity in patients with severe neurologic impairment
- Pilot study of gas chromatographic-mass spectrometric screening of newborn urine for inborn errors of metabolism after treatment with urease
- An infant with 3 β -hydroxy-△^5-C_-steroid dehydrogenase/isomerase deficiency presenting with typical neonatal hepatitis syndrome : The first Japanese case
- Sepsis in children
- Histological findings in the livers of patients with neonatal intrahepatic cholestasis caused by citrin deficiency
- Neonatal ketosis is not rare : experience of neonatal screening using gas chromatography-mass spectrometry
- Urinary 1β-hydroxyursodeoxycholic acid during ursodeoxycholic acid therapy
- Transient Expression of a Brain/Embryonic-Type Myosin Heavy Chain Isoform (MIIB2) in Regenerating Rat Liver
- Structure of the respiratory tract of the red-bellied newt Cynops pyrrhogaster, with reference to serotonin-positive neuroepithelial endocrine cells
- Conducting Polymer-coated Electrode as a Reference/Counter Electrode in an Organic Phase and Its Application to a Two-electrode Type Thin-layer Cell for Voltammetry at the Liquid | Liquid Interface
- Interfacial-specific Chemiluminescence at Liqud/Liquid Interfaces or at O/W Emulsions Containing Lucigenin in Oil Phase
- Selective Ion Transfer Accompanied by a Respiration Mimetic Reaction at an Aqueous/Organic Solutions Interface
- The role of proton transfer on the redox process of vitamin E at the water : 1, 2-dichloroethane interface
- Non-Bornian Ion Solvation Energy. An Approach from Redox Potentials of Heteropoly Oxometalate Anions
- Gastrointestinal Stromal Tumor of the Stomach : Report of a Case
- Cutaneous mixed tumors : an immunohistochemical study using two antibodies, G-81 and C8/144B
- Oscillations of Membrane Current or Membrane Potential and Voltammetric Elucidation of Their Mechanisms
- New Morphological Aspects of the Brush Cells in the Main Excretory Ducts of the Rat Submandibular Glands : Cell Biology
- 急性ロタウイルス胃腸炎における超音波検査所見と臨床症状
- Theory of the Transient Potential Response of Ion-Selective Electrodes Based on the Polarizable Oil/Water Interface
- 早期産児における尿中胆汁酸組成の発達的推移
- Re-attachment of a Tendon to the Calcified Fibrocartilage Layer
- Liver biopsy is an important procedure in the diagnosis of glycogen storage disease type IV
- 生体反応に類似した電荷の水溶液/有機溶液界面,人工液膜移動反応
- 3PT159 BLMを介したイオン性蛍光プローブの膜透適性 : 電流と蛍光に基づいた動的解析(日本生物物理学会第50回年会(2012年度))
- 3PS021 イオン移動ポルタンメトリーに基づく微量ペプチドの物質量決定(日本生物物理学会第50回年会(2012年度))
- Measurement of Transport Activities of 3β-Hydroxy-Δ5-bile Acids in Bile Salt Export Pump and Multidrug Resistance-Associated Proteins Using LC-MS/MS
- Propagation and Synchronization of Potential Oscillations in Multiple Liquid Membrane Systems
- Placental Transport of Bile Acids: Analysis of Bile Acids in Maternal Serum and Urine, Umbilical Cord Blood, and Amniotic Fluid.
- The benzannelated annulenones. Syntheses and properties of 12-methylbenzo[f]- and dibenzo[f,l]-8,10-bisdehydro[17]annulenone.
- Large Amounts of 1.BETA.-Hydroxylated Bile Acids in Urine during Taurine Therapy.
- Expression of Histo-Blood Group A Type 1, 2 and 3 Antigens in Normal Skin and Extramammary Paget's Disease