Large Amounts of 1.BETA.-Hydroxylated Bile Acids in Urine during Taurine Therapy.
スポンサーリンク
概要
- 論文の詳細を見る
The management of infants with cholestasis remains a difficult challenge. On the hypothesis that taurine is effective in treating neonatal cholestasis, taurine (1 g/day, per os) was administered to 2 patients with neonatal hepatitis and the bile acids were analyzed using gas chromatographymass spectrometry (GC-MS). The serum levels of bilirubin and bile acids were significantly decreased by taurine. Before the treatment, cholic acid (CA) and chenodeoxycholic acid (CDCA) were predominant (79.2% in both patients) in the urine. There was a significant elevation of 1β-hydroxylated bile acids (1βBA), especially 1β, 3α, 7α, 12α-tetrahydroxy-5β-cholan-24-oic acid (CA-1β-ol), in urine collected during the taurine therapy, and 1βBA became predominant (57.7- 78.3%). Therefore, increased amounts of urine 1βBA were excreted during taurine administration. Taurine therapy is recommended, because it might be effective for treating neonatal cholestasis.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
-
Kimura Akihiko
Department Of Anatomy School Of Medicine Toho University
-
Ushijima Kosuke
Department Of Pediatrics And Child Health Kurume University School Of Medicine
-
Inokuchi Takahiro
Research Institute Of Medical Mass Spectrometry Kurume University School Of Medicine
-
Yamakawa Ryoichi
Department Of Pediatrics And Child Health Kurume University School Of Medicine
-
Kage Masayoshi
Department Of Diagnostic Pathology Kurume University Hospital
-
TOHMA MASAHIKO
Faculty of Pharmaceutical Science, Higashi-Nippon-Gakuen University
-
MAHARA REIJIRO
Faculty of Pharmaceutical Science, Higashi-Nippon-Gakuen University
関連論文
- Impaired Filterability of Erythrocytes from Patients with Chronic Hepatitis C and Effects of Eicosapentaenoic Acid on the Filterability
- Proposal of histological criteria for intraepithelial atypical/proliferative biliary epithelial lesions of the bile duct in hepatolithiasis with respect to cholangiocarcinoma : Preliminary report based on interobserver agreement
- 先天性胆汁酸代謝異常症の尿中胆汁酸分析依頼システム : 本邦における10年間の成績
- VASOACTIVE INTESTINAL POLYPEPTIDE AND CALBINDIN-D28K IMMUNOREACIVE NEURONS IN THE OLFACTORY BULB OF THE MUSK SHREW, SUNCUS MURINUS(Cell Biology and Morphology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- Diagnosing clinical subsets of autoimmune liver diseases based on a multivariable model
- Are bile duct lesions of primary biliary cirrhosis distinguishable from those of autoimmune hepatitis and chronic viral hepatitis? Interobserver histological agreement on trimmed bile ducts
- Tyrosinemia type I-like disease : A possible manifestation of 3-oxo-△^4-steroid 5β-reductase deficiency
- Thiolase Involved in Bile Acid Formation^1
- Determination of 3-oxo-Δ^4- and 3-oxo-Δ^-bile acids and related compounds in biological fluids of infants with cholestasis by gas chromatography-mass spectrometry
- Determination of fetal bile acids in biological fluids from neonates by gas chromatography-negative ion chemical ionization mass spectrometry
- STEREOSPECIFIC FORMATION OF (24R, 25R)-3α, 7α, 12α, 24-TETRAHYDROXY-5β-CHOLESTAN-26-OIC ACID CATALYZED WITH A PEROXISOMAL BIFUNCTIONAL D-3-HYDROXYACYL-CoA DEHYDRATASE/D-3-HYDROXYACYL-CoA DEHYDROGENASE
- Capillary Gas Chromatographic Determination of C_-Bile Acids in Biological Samples and Its Application to the Urine of a Patient with Zellweger Syndrome
- Simultaneous Fluorometric Determination of Conjugated Fetal Bile Acids in Urine of Newborns by High-Performance Liquid Chromatography
- Profile Analysis of Bile Acids in Human Fetal and Neonatal Periods by Gas Chromatography-Mass Spectrometry
- Biotin-related proteins of 70 and 72 kDa in gallbladder bile in primary biliary cirrhosis
- Pleomorphic carcinoma of the breast in a 17-year-old woman
- Novel mutations in five Japanese patients with 3-methylcrotonyl-CoA carboxylase deficiency
- Epidemiology of Helicobacter pylori infection in children : A serologic study of the Kyushu region in Japan
- Mesenchymal Hamartoma of the Liver Accompanied by a Daughter Nodule : Report of a Case
- Gastric enterochromaffin-like-cell tumor with liver and splenic metastases
- Severe brainstem compression by an unruptured giant vertebral aneurysm : An autopsy case
- Preclinical studies of molecular-targeting diagnostic and therapeutic strategies against breast cancer
- Perinatal bile acid metabolism : bile acid analysis of meconium of preterm and full-term infants
- Acute severe hepatitis : Successful prevention of fulminant hepatic failure with early intensive medical therapy
- Two neonates with intussusception accompanying severe hypoxia
- Abnormally low ratio of cholic acid to chenodeoxycholic acid due to a deficiency of 3-oxo-Δ^4-steroid 5β-reductase
- Guidelines for care of pregnant women carrying hepatitis C virus and their infants
- A possible mechanism of neonatal intrahepatic cholestasis caused by citrin deficiency
- Adenomyoepithelioma of the Breast Diagnosed by a Mammotome Biopsy : Report of a Case
- FIBROMUSCULAR LAYER IN THE RESPIRATORY TRACT OF RED-BELLIED NEWT (CYNOPS PYRRHOGASTER)(Cell Biology and Morphology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- DISTRIBUTION OF NEE CELLS AND NEBS IN THE RESPIRATORY TRACT OF RED-BELLIED NEWT (CYNOPS PYRRHOGASTER)(Cell Biology and Morphology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- LOCALIZATION OF SEROTONIN-IMMUNOREACTIVE CELLS IN THE RESPIRATORY TRACT OF URODELA : THE TAILED AMPHIBIANS(Cell Biology and Morphology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- Gene expression of cytokines and growth factors in the lungs after paraquat administration in mice
- Budd-Chiari syndrome and hepatocellular carcinoma
- What features of the pathological morphology of the liver increase the accuracy of diagnostic imaging for cirrhosis?
- 潰瘍性大腸炎患児における血球浄化療法
- Helicobacter pylori seropositivity in patients with severe neurologic impairment
- DETERMINATION OF THE UNUSUAL BILE ACID, 3β, 12α-DI-HYDROXY-5-CHOLENOIC ACID IN HUMAN SERUM BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY
- Pilot study of gas chromatographic-mass spectrometric screening of newborn urine for inborn errors of metabolism after treatment with urease
- An infant with 3 β -hydroxy-△^5-C_-steroid dehydrogenase/isomerase deficiency presenting with typical neonatal hepatitis syndrome : The first Japanese case
- The Patterns of Pitfalls in the Application of Smooth Muscle Actin (SMA) Immunostaining for Breast Cytological Analyses
- A historical view of schistosomiasis japonica in the Chikugo river basin. What can we learn from autopsy?
- Pathology of autoimmune liver diseases in children
- Histological findings in the livers of patients with neonatal intrahepatic cholestasis caused by citrin deficiency
- Serum hyaluronate level correlates to the degree of liver fibrosis in pediatric liver diseases
- Determination of Peroxidase with a Chemiluminescence Reaction of Homogentisic Acid γ-Lactone in Non-Aqueous Media
- Neonatal ketosis is not rare : experience of neonatal screening using gas chromatography-mass spectrometry
- Urinary 1β-hydroxyursodeoxycholic acid during ursodeoxycholic acid therapy
- Clinicocytopathology of breast cancers with a ring-like appearance on ultrasonography and/or magnetic resonance imaging
- Transient Expression of a Brain/Embryonic-Type Myosin Heavy Chain Isoform (MIIB2) in Regenerating Rat Liver
- Structure of the respiratory tract of the red-bellied newt Cynops pyrrhogaster, with reference to serotonin-positive neuroepithelial endocrine cells
- Clinicopathological study of invasive ductal carcinoma with large central acellular zone : Special reference to magnetic resonance imaging findings
- Effect of omeprazole on the course of associated esophagitis and laryngitis
- QUANTITATIVE DETERMINATION OF CONJUGATED FETAL BILE ACIDS IN URINE BY CHEMILUMINESCENCE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY
- Gastrointestinal Stromal Tumor of the Stomach : Report of a Case
- Cutaneous mixed tumors : an immunohistochemical study using two antibodies, G-81 and C8/144B
- New Morphological Aspects of the Brush Cells in the Main Excretory Ducts of the Rat Submandibular Glands : Cell Biology
- 急性ロタウイルス胃腸炎における超音波検査所見と臨床症状
- Accuracy of differential diagnosis for pancreatic cancer is improved in the combination of RCAS1 and CEA measurements and cytology in pancreatic juice
- 早期産児における尿中胆汁酸組成の発達的推移
- Re-attachment of a Tendon to the Calcified Fibrocartilage Layer
- Preface
- Application of a new histological staging and grading system for primary biliary cirrhosis to liver biopsy specimens : Interobserver agreement
- Liver biopsy is an important procedure in the diagnosis of glycogen storage disease type IV
- Pulmonary Metastasis of Endometrial Stromal Sarcoma
- A Case of a Primary Hepatic Tumor Causing Segmental Changes on Imaging and Its Relation to Zahns Infarct
- Immunohistochemical study of metaplastic carcinoma and central acellular carcinoma of the breast : central acellular carcinoma is related to metaplastic carcinoma
- Concurrent Lung Cancer in Non-Tuberculous Mycobacteriosis: Case Report
- Giant Malignant Phyllodes Tumor: A Case Report
- Blood Pressure Variability Activates Cardiac Mineralocorticoid Receptor and Induces Cardiac Remodeling in Hypertensive Rats
- Measurement of Transport Activities of 3β-Hydroxy-Δ5-bile Acids in Bile Salt Export Pump and Multidrug Resistance-Associated Proteins Using LC-MS/MS
- The pathogenesis of idiopathic portal hypertension (so-called Banti's disease). An experimental study.:An Experimental Study
- Esophageal varices treated with endoscopic injection sclerotherapy A pathological study.:A Pathological Study
- Comparison of Preoperative Fine-needle Aspiration Cytology Diagnosis and Histopathological Diagnosis of Salivary Gland Tumors
- Placental Transport of Bile Acids: Analysis of Bile Acids in Maternal Serum and Urine, Umbilical Cord Blood, and Amniotic Fluid.
- The benzannelated annulenones. Syntheses and properties of 12-methylbenzo[f]- and dibenzo[f,l]-8,10-bisdehydro[17]annulenone.
- Incidence of Hepatitis D Virus Infection in Japanese Patients with Hepatocellular Carcinoma Immunohistochemical Investigation of the Delta Antigen.:Immunohistochemical Investigation of the Delta Antigen
- Hepatocellular adenoma related to oral contraceptive use. Report of two cases.:Report of Two Cases
- Spontaneous peritonitis of liver cirrhosis - an autopsy case.:An Autopsy Case
- Pathological studies on the liver with extrahepatic portal obstruction.
- Histological progression of the hepatic lesions in idiopathic portal hypertension(Banti's disease). Observations from 25 autopsies.:Observations from 25 Autopsies
- Development of intrahepatic cholangiocarcinoma after a 14-year follow-up of a patient with primary sclerosing cholangitis and ulcerative colitis
- Large Amounts of 1.BETA.-Hydroxylated Bile Acids in Urine during Taurine Therapy.
- Expression of Histo-Blood Group A Type 1, 2 and 3 Antigens in Normal Skin and Extramammary Paget's Disease
- Decreased expression of insulin and increased expression of pancreatic transcription factor PDX-1 in islets in patients with liver cirrhosis : a comparative investigation using human autopsy specimens
- Large Blood Pressure Variability Aggravates Arteriolosclerosis and Cortical Sclerotic Changes in the Kidney in Hypertensive Rats
- Clinicopathological significance of hypoxia-inducible factor-1 alpha (HIF-1α) expression in gastric cancer
- Blood Pressure Variability Activates Cardiac Mineralocorticoid Receptor and Induces Cardiac Remodeling in Hypertensive Rats