The pathogenesis of idiopathic portal hypertension (so-called Banti's disease). An experimental study.:An Experimental Study
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概要
- 論文の詳細を見る
The pathogenesis of idiopathic portal hypertension (IPH) was explored in animal experiments. In order to produce experimentally a condition of portal hypertension, portal vein embolization by lycopodiums and structural liver damage by intraportal injection of toxic chemicals were produced in rabbits. Obliteration of intrahepatic portal vein branches alone did not produce sustained portal hypertension due to the development of adequate intrahepatic collateral vessels. Liver damage induced by chemicals was morphologically similar to that seen in IPH and was associated with an increase of portal venous pressure for several months; however, portal venous pressure gradually declined and significant splenomegaly could not be produced. Besides hepatic vascular resistance due to obliteration of intrahepatic portal vein branches and structural liver damage, the possibility of the existence of additional factor (s) is suggested to explain portal hypertension and marked splenomegaly in IPH.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Matsumoto Shin
Department Of Cardiology Tama-nagayama Hospital Nippon Medical School
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Fukuda Kazunori
Department Of Material And Life Science Graduate School Of Engineering Osaka University
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Kage Masayoshi
Department Of Diagnostic Pathology Kurume University Hospital
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Arakawa Masahiro
Department of Internal Medicine, Ishinomaki Red Cross Hospital
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FUKUDA KAZUNORI
Department of Pathology, Kurume University School of Medicine
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NAKASHIMA TOSHIRO
Departments of Pathology Kurume University School of Medicine
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MATSUMOTO SHIN
Department of Pathology, Kurume University School of Medicine
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NAKASHIMA TOSHIRO
Department of Pathology, Kurume University School of Medicine
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NAKASHIMA TOSHIRO
Department of Pathology Kurume University School of Medicine
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