Structural alterations in c-myc and c-Ha-ras proto-oncogenes in human hepatocellular carcinoma.
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概要
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Cellular DNAs from 64 human hepatocellular carcinomas (HCCs) and 4 human HCC cell lines were studied for gross structural alterations in c-myc and c-Ha-ras proto-oncogenes. A 12th codon mutation of the c-Ha-ras gene in the DNA of one tumor tissue and a 3 to 4-fold amplification of the c-myc gene in that of 2 tumor tissues were found. There was no gross DNA rearrangement of c-myc and c-Ha-ras genes or significant gene amplification of the c-Ha-ras gene in any of the tumor tissues or cell line DNAs. Although these results do not exclude the possibility that more subtle changes occur in these proto-oncogenes that play some role in human hepatocarcinogenesis, the 12th codon mutation of the c-Ha-ras gene and gross structural alterations, such as DNA rearrangement or gene amplification of c-myc and c-Ha-ras genes, appear to occur in a minority of human HCCs.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Kojiro Masamichi
Department Of Gastroenterology And Hepatology Kinki University School Of Medicine
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Fukuda Kazunori
Department Of Material And Life Science Graduate School Of Engineering Osaka University
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Yano Hirohisa
Department Of Pathology Kurume University School Of Medicine
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Murakami Tatsuo
Department Of Anesthesia Gifu Red Cross Hospital
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Ogasawara Sachiko
Department Of Pathology Kurume University School Of Medicine
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MARUIWA MASAFUMI
Department of Surgery, Kurume University School of Medicine
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FUKUDA KAZUNORI
Department of Pathology, Kurume University School of Medicine
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MARUIWA MASAFUMI
Department of Pathology, Kurume University School of Medicine
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