Alpha-Fetoprotein-Producing Rectal Carcinoma. A Case Report.:A Case Report
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概要
- 論文の詳細を見る
A case with an alpha-fetoprotein (AFP)-producing carcinoma originating from the rectum is described. A 71-year-old male patient, who underwent a rectectomy for rectal carcinoma, developed space occupying lesions in the liver and a remarkable AFP elevation (220, 000ng/ml) in the 6th month postoperatively, and then expired one year later. Histologically, the rectal carcinoma consisted of well-differentiated adenocarcinomas, and contiguous cancerous cells proliferating in either a medullary or trabecular pattern. In the "trabecular" areas, localization of AFP was confirmed immunohistochemically. Results of concanavalin A or lens culinarisd agglutinin affinity chromatography demonstrated that it was between a hepatic type and a yolk sac type, and was considered to be an intestinal type. This could have been an AFP-producing rectal carcinoma, in which the patient experienced liver metastasis at a relatively early postoperative period and died. This shows that AFP-producing rectal carcinomas are highly malignant, biologically, similar to AFP-producing gastric cancers.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Kojiro Masamichi
Department Of Gastroenterology And Hepatology Kinki University School Of Medicine
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Yano Hirohisa
Department Of Pathology Kurume University School Of Medicine
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Yamaguchi Rin
Department Of Pathology Cancer Institute
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Sueda Jun
Department Of Ophthalmology Kurume University School Of Medicine
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TAGUCHI Jun
Department of Chemistry and Materials Science Tokyo Institute of Technology
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YAMAGUCHI RIN
Department of Pathology, Kurume University School of Medicine
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SHIROUZU GENZAN
Miki Hospital
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HASHIMOTO KEN
Miki Hospital
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