Elevated Levels of Thioredoxin 1 in the Lungs and Sera of Idiopathic Pulmonary Fibrosis, Non-Specific Interstitial Pneumonia and Cryptogenic Organizing Pneumonia

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概要

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• Objective Oxidant stress is thought to be involved in the establishment of idiopathic interstitial pneumonia (IIP). Thioredoxin 1 (TRX1) plays a role as a strong antioxidant in vivo, suggesting that TRX1 may be involved in the pathogenesis of IIPs. However, there is no report on TRX1 levels in the sera of IIPs. In addition, TRX1 expression in the lungs of non-specific interstitial pneumonia (NSIP) and cryptogenic organizing pneumonia (COP) patients also has not been reported. Here, we investigated whether or not TRX1 levels are altered in the lungs and sera of patients with idiopathic pulmonary fibrosis (IPF), NSIP, and COP. Methods Immunohistochemical analysis was performed to examine the expression of TRX1. TRX1 levels in sera were measured using an ELISA kit. Results TRX1 was expressed in the bronchiole-alveolar epithelium, especially with regenerative or metaplastic feature, and in alveolar macrophages in usual interstitial pneumonia (UIP) and fibrotic NSIP. TRX1 was weakly expressed in the lungs of cellular NSIP and COP. TRX1 producing cells in UIP (n=16), fibrotic NSIP (n=15), cellular NSIP (n=4), and COP (n=5) were significantly increased when compared to nonsmokers (n=7). TRX1 producing cells in UIP and fibrotic NSIP were significantly increased when compared to cellular NSIP and COP. TRX1 levels in the sera of the patients with IPF (n=32; 74.2 ± 7.5 ng/mL), fibrotic NSIP (n=7; 82.5 ± 18.4 ng/mL), cellular NSIP (n=3; 62.2 ± 3.2 ng/mL) and COP (n=17; 88.8 ± 19.7 ng/mL) were significantly higher than those of control subjects (n=74; 35.3 ± 2.7 ng/mL). Furthermore, TRX1 levels in the sera of IPF patients who later showed acute exacerbation (n=7; 106.6 ± 16.3 ng/mL) were significantly higher than those of IPF patients without acute exacerbation (n=25; 65.1 ± 7.6 ng/mL). Conclusion Overproduction of TRX1 in the lungs and sera may play an important role in the pathogenesis of IIPs.

著者

• Azuma Koichi

  Division Of Respirology Neurology And Rheumatology Department Of Internal Medicine Kurume University

• Okamoto Masaki

  Division Of Respirology Neurology And Rheumatology Department Of Medicine Kurume University School O

• Kato Seiya

  Division Of Diagnostic Radiology And Division Of Nuclear Technology Kurume University Hospital

• Aizawa Hisamichi

  Division Of Respirology Neurology And Rheumatology Department Of Internal Medicine Kurume University

• Fujimoto Kiminori

  Department Of Radiology Kurume University School Of Medicine

• Yano Hirohisa

  Department Of Pathology Kurume University School Of Medicine

• Hoshino Tomoaki

  Division Of Respirology Neurology And Rheumatology Department Of Internal Medicine Kurume University

• Sakazaki Yuki

  Division Of Respirology Neurology And Rheumatology Department Of Medicine Kurume University School O

• Imaoka Haruki

  Division Of Respirology Neurology And Rheumatology Department Of Medicine Kurume University School O

• Kinoshita Takashi

  Division Of Head And Neck Chiba Cancer Center Hospital

• KINOSHITA Takashi

  Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine

• Kitasato Yasuhiko

  Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Japan

• KAWAYAMA TOMOTAKA

  Division of Respiratory Medicine, Social Insurance Tagawa Hospital

• Iwata Yasuhiro

  Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine

• Tajiri Morihiro

  Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine

• Matsunaga Kazuko

  Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine

• Azuma Koichi

  Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine

• Kitasato Yasuhiko

  Division of Respirology, Neurology, and Rheumatology, Department of Medicine, Kurume University School of Medicine

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