Successful Treatment with Tacrolimus in a Case of Lung-dominant Connective Tissue Disease
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概要
- 論文の詳細を見る
A 49-year-old man with dyspnea was found to have reticular opacities and ground-glass attenuation with traction bronchiectasis or bronchiolectasis on computed tomography. The patient met the criteria for lungdominant connective tissue disease (LD-CTD) and histopathologically exhibited a chronic fibrotic interstitial pneumonia illustrating framework of a usual interstitial pneumonia-like pattern. Due to worsening of the disease, therapy was initiated with corticosteroids in combination with cyclosporine A. However, treatment with these drugs was ineffective. Pirfenidone and intravenous cyclophosphamide therapy also proved ineffective. The cyclosporine A was therefore switched to tacrolimus, and the patient's disease improved, allowing for a reduction in the dose of the corticosteroids. Our experience in this case suggests that treatment with tacrolimus might be useful for treating refractory LD-CTD even when histopathologically chronic fibrotic interstitial pneumonia is evident.
- 日本内科学会の論文
著者
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Kawayama Tomotaka
Division Of Respirology Neurology And Rheumatology Department Of Medicine Kurume University School O
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Okamoto Masaki
Department Of Applied And Bioapplied Chemistry Graduate School Of Engineering Osaka City University
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Fujimoto Kiminori
Department Of Radiology Kurume University School Of Medicine
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Fukuoka Junya
Department Of Neurosurgery Faculty Of Medicine University Of Toyama And Laboratory Of Pathology Toya
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Hoshino Tomoaki
Division Of Respirology Neurology And Rheumatology Department Of Internal Medicine Kurume University
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Nakamura Masayuki
Department Of Animal Science Faculty Of Agriculture Tohoku University
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YOSHIDA Tsukasa
Department of Anesthesiology, Sapporo Medical University School of Medicine
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ICHIKI MASAO
Department of Medicine, Kurume University School of Medicine
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Kawayama Tomotaka
Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Japan
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Idemoto Akiko
Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Japan
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Kitasato Yasuhiko
Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Japan
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KAWAYAMA TOMOTAKA
Division of Respiratory Medicine, Social Insurance Tagawa Hospital
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Fujimoto Kiminori
Department of Radiology, Kurume University School of Medicine, Japan
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Ichiki Masao
Department of Respirology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan
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Okamoto Masaki
Department of Respirology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan
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Hoshino Tomoaki
Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Japan
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