Malignant Pleural Effusion from Lung Adenocarcinoma Treated by Gefitinib
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概要
- 論文の詳細を見る
Small molecule inhibitors targeting epidermal growth factor receptor (EGFR) are known to be active against non-small cell lung cancer (NSCLC) although the pharmacodynamics of these agents on malignant pleural effusion (MPE) remains unclear. Here we describe a case of lung adenocarcinoma with massive MPE treated successfully by gefitinib and chest drainage. Using sequential MPE samples before and during gefitinib therapy, the morphological changes and apoptosis of cancer cells were analyzed. Apoptosis of cancer cells was detected as early as 4 hours on, but not before, gefitinib therapy, suggesting that the pharmacodynamic assessment of such molecular targeting agents might be feasible for MPE.
著者
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Fukuoka Junya
Department Of Neurosurgery Faculty Of Medicine University Of Toyama And Laboratory Of Pathology Toya
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Okamoto Isamu
Department Of Medical Oncology Kinki University School Of Medicine
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Nakagawa Kazuhiko
Department Of Chemistry And Materials Technology Faculty Of Engineering And Design Kyoto Institute O
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Kitaichi Masanori
National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
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Kubo Akihito
National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
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Fukuoka Junya
Department of Pathology, Toyama University School of Medicine, Japan
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Koh Yasuhiro
Drug Discovery and Development Division, Shizuoka Cancer Center Research Institute, Japan
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Kawaguchi Tomoya
National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
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Isa Shun-Ichi
National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
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Kusunoki Yoko
National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
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Takada Minoru
National Hospital Organization Kinki-Chuo Chest Medical Center, Japan
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