Cortisol Δ^1-Dehydrogenation by Cells of Arthrobacter simplex Immobilized by Capture on the Surface of Unwoven Cloth Coated with a Pyridinium-Type Polymer
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概要
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Cells of Arthrobacter simplex having 3-ketosteroid-Δ^1-dehydromonogenase activity were immobilized by capture on the surface of unwoven cloth, which was coated with a copolymer of N-benzyl-4-vinylpyridinium chloride and styrene(soluble BVPS), a pyridinium-type polymer. The captured bacterial cells catalyzed the dehydrogenation of cortisol to prednisolone in solvents containing methanol. A fixed-bed column reactor 15mm in diameter and 12cm long was continuously operated. The reactor contained about 200mg of A. simplex cells, captured on an unwoven cloth 12cm wide, 20cm long, and 0.5mm thick coated with 6.5g/m^2 of the soluble BVPS, and yielded approximately 90% prednisolone during 6d when tha influent cortisol concentration was 1.0mmol/l and the space velocity was 0.57h^<-1> at 20℃ and pH8.2.
- 公益社団法人日本生物工学会の論文
- 1991-01-25
著者
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Kawabata Nariyoshi
Department Of Chemistry And Materials Technology Faculty Of Engineering And Design Kyoto Institute O
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Nakagawa Kazuhiko
Department Of Chemistry And Materials Technology Faculty Of Engineering And Design Kyoto Institute O
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