Phase I Study of a Combination of Irinotecan and Ifosfamide in Advanced Primary Lung Cancer.
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概要
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We sought to investigate cisplatin-free chemotherapy for patients with primary lung cancer. We therefore conducted a Phase II study to identify; a) the maximum tolerated dose (MTD) of irinotecan (CPT-11) given with a fixed dose of ifosfamide (IFM), and b) the principal toxic effects associated with this regimen in a Phase I study. A total of 27 patients with previously treated or untreated primary lung cancer received CPT-11 on days 1, 8 and 15 in combination with a fixed dose of IFM, 1.5 g/m<SUP>2</SUP>/day, on days 1 through 3, given every 4 weeks. The starting dose of CPT-11 was 30 mg/m<SUP>2</SUP>, which was increased by amounts of 10 mg/m<SUP>2</SUP>. Four patients were assigned to different dosage levels, and drug toxicity was evaluated for the first 2 cycles. The MTD of OPT-11 was 90 mg/m<SUP>2</SUP>, with leukopenia being the dose-limiting effect. The response rate was 43% (6/14;1 complete response) in non-small cell lung cancer, and 78% (7/9; no complete response) in small cell lung cancer. The recommended dose of CPT-11 for a Phase II study is thus 80 mg/m<SUP>2</SUP> on days 1, 8 and 15 with IFM 1.5 g/m<SUP>2</SUP> given on days 1 through 3. This regimen appears particularly encouraging, because of its low toxicity. Phase II trials of the combination are indicated.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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OIZUMI Kotaro
Department of Internal Medicine, Kurume University
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Gohara Rumi
Department Of Biomolecular Sciences Faculty Of Medicine Saga University
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Kawayama Tomotaka
Department Of Medicine Kurume University
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Kinoshita Masaharu
Department of Applied Physics, Graduate School of Engineering, Osaka University, 2-1 Yamada-oka, Suita, Osaka 565-0871, Japan
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RIKIMARU TORU
Department of Medicine, Kurume University School of Medicine
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ICHIKI MASAO
Department of Medicine, Kurume University School of Medicine
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OKUBO YO
Department of Medicine, Kurume University School of Medicine
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MITUI TAKASHI
Department of Medicine, Kurume University School of Medicine
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