Antiphospholipid Syndrome and Multiple Ischemic Strokes in a Patient with Myasthenia Gravis.
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概要
- 論文の詳細を見る
Little is known about ischemic stroke occurrence in patients with myasthenia gravis (MG), although antiphospholipid antibodies are detectable in many MG patients. A 47-year-old woman with a 20-year history of generalized MG had an acute onset of right hemiparesis. She had undergone thymectomy 10 years previously and was treated for phlebothrombosis of the lower extremity 3 years previously. Computed tomography (CT) demonstrated an old infarct in the left frontal lobe and a new lesion in the right parietal lobe. Multiple small cortical and subcortical infarcts were demonstrated on fluid attenuated inversion recovery (FLAIR) images. Thrombocytopenia (5.9×10<SUP> </SUP>4/μL), a prolonged activated partial thromboplastin time (aPTT; 50.2 sec), and an elevation of β<SUP>2</SUP>-lgG-glycoprotein I anticardiolipin antibodies (β<SUP>2</SUP>-GPIaCL; 55.7 U/mL) were observed. Neurological defects improved significantly over 2 weeks. She then was treated with oral prednisolone (30 mg/day) for 18 months, with resolution of laboratory abnormalities and no new cerebrovascular events or findings on imaging. We believe that our patient's multiple infarcts are caused by antiphospholipid antibodies and recommend glucocorticoid therapy to prevent recurrent of ischemic stroke in similar case.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Abe Toshi
Department Of Radilogy School Of Medicine Kurume University
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OIZUMI Kotaro
Department of Internal Medicine, Kurume University
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Kaji Masahide
Department Of Internal Medicine Kurume University Medical Center
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Aizawa Hisamichi
Department Of Medicine Division Of Respirology Neurology And Rheumatology Kurume University School O
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Sato Yoshihiro
Department of Applied Biological Science, Tokyo University of Science
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Watanabe Aya
Department of Chemistry and Chemical Biology, Graduate School of Engineering, Gunma University
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AIZAWA HISAMICHI
Departments of Medicine, Kurume University School of Medicine
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ABE TOSHI
Departments of Radiolog, Kurume University School of Medicine
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KUNOH HARUKO
Department of Neurology, Kurume University Medical Center
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OIZUMI KOTARO
Departments of Medicine, Kurume University School of Medicine
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