Comparative Effects of Vitamin K and Vitamin D Supplementation on Calcium Balance in Young Rats Fed Normal or Low Calcium Diets
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概要
- 論文の詳細を見る
We examined the effect of vitamin K and vitamin D supplementation on calcium balance in young rats fed a normal or low calcium diet. Eighty female Sprague-Dawley rats, 6 wk of age, were randomized by the stratified weight method into eight groups with 10 rats in each group : 0.5% (normal) or 0.1% (low) calcium diet, 0.5% or 0.1% calcium diet+vitamin K (vitamin K_2, menatetrenone, 30mg/100g, food intake), 0.5% or 0.1% calcium diet+vitamin D (25μg/100g, food intake), and 0.5% or 0.1% calcium diet+vitamin K+vitamin D. The duration of the study was 10wk. Vitamin K supplementation promoted the reduction in urinary calcium excretion and retarded the abnormal elevation of serum PTH level in rats fed a low calcium diet, and stimulated intestinal calcium absorption in rats fed a normal calcium diet. Vitamin D supplementation stimulated intestinal calcium absorption with prevention of the abnormal elevation of serum PTH levels and prevented hypocalcemia in rats fed a low calcium diet, and stimulated intestinal calcium absorption in rats fed a normal calcium diet. The stimulation of intestinal calcium absorption was associated with increased serum 1, 25-dihydroxyvitmain D levels. An additive effect of vitamin K and vitamin D on intestinal calcium absorption was found only in rats fed a normal calcium diet. This study shows the differential effects of vitamin K and vitamin D supplementation on calcium balance in young rats fed a normal or low calcium diet.
- 日本ビタミン学会の論文
著者
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SATO Yoshihiro
Department of Materials Science and Engineering, Faculty of Engineering, Osaka University
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Sato Yoshihiro
Mitate Hospital Fukuoka Jpn
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Takeda Tsuyoshi
Department Of Geriatric Medicine Osaka University Graduate School Of Medicine
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YEH James
Metabolism Laboratory, Department of Medicine, Winthrop-University Hospital
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Iwamoto J
Institute For Integrated Sports Medicine Keio University School Of Medicine
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Yeh James
Metabolism Laboratory Department Of Medicine Winthrop-university Hospital
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Iwamoto Jun
Department Of Sports Medicine Keio University School Of Medicine
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Iwamoto Jun
Department Of Orthopaedic Surgery School Of Medicine Keio University
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TAKEDA Tsuyoshi
Institute for Integrated Sports Medicine, Keio University School of Medicine
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Takeda Tsuyoshi
Institute For Integrated Sports Medicine Keio University School Of Medicine
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Takeda Tsuyoshi
Department Of Electrical And Electronic Engineering Faculty Of Mining Akita University
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Sato Yoshihiro
Department Of Materials Science And Engineering Faculty Of Engineering Osaka University
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Sato Yuki
Department Of Integrated Biosciences Graduate School Of Frontier Sciences The University Of Tokyo
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Sato Yoshihiro
Department Of Biochemistry Kyoritsu College Of Pharmacy
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Sato Yoshihiro
Department of Applied Biological Science, Tokyo University of Science
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