アレンドロネートとアルファカルシドールが卵巣摘出ラットの海綿骨および皮質骨の骨量と骨強度におよぼす効果
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概要
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The purpose of the present study was to compare the effects of alendronate and alfacalcidol on cancellous and cortical bone mass and bone mechanical properties in ovariectomized rats. Twenty-six female Sprague-Dawley rats, 7 months of age, were randomized by the stratified weight method into four groups: the sham-operated control (Sham) group and the three ovariectomy (OVX) groups, namely, OVX + vehicle, OVX + alendronate (2.5 mg/kg, p.o., daily), and OVX + alfacalcidol (0.5 μg/kg, p.o., daily). At the end of the 8-week experimental period, bone histomorphometric analyses of cancellous bone at the proximal tibial metaphysis and cortical bone at the tibial diaphysis were performed, and the mechanical properties of the femoral distal metaphysis and femoral diaphysis were evaluated. OVX decreased cancellous bone volume per total tissue volume (BV/TV), and the maximum load of the femoral distal metaphysis, as a result of increases in serum osteocalcin (OC) levels, and also the number of osteoclasts (N.Oc), osteoclast surface (OcS) and bone formation rate (BFR) per bone surface (BS), and BFR/BV, without any effect on cortical area (Ct Ar), or maximum load of the femoral diaphysis. Alendronate prevented this decrease in cancellous BV/TV by suppressing increases in N.Oc/BS, OcS/BS, BFR/BS, and BFR/BV, without any apparent effect on Ct Ar, or maximum load of the femoral distal metaphysis and femoral diaphysis. On the other hand, alfacalcidol increased cancellous BV/TV, Ct Ar, and the maximum load of the femoral distal metaphysis and femoral diaphysis, by mildly decreasing trabecular BFR/BV, maintaining trabecular mineral apposition rate and osteoblast surface per BS, increasing periosteal and endocortical BFR/BS, and preventing an increase in endocortical eroded surface per BS. The present study clearly showed the differential skeletal effects of alendronate and alfacalcidol in ovariectomized rats. Alendronate prevented OVX-induced cancellous bone loss by suppressing bone turnover, while alfacalcidol improved cancellous and cortical bone mass and bone strength by suppressing bone resorption and maintaining or even increasing bone formation.
- 社団法人 日本実験動物学会の論文
- 2006-07-01
著者
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岩本 潤
Department of Orthopaedic Surgery, School of Medicine, Keio University
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SATO Yoshihiro
Department of Materials Science and Engineering, Faculty of Engineering, Osaka University
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Sato Yoshihiro
Mitate Hospital Fukuoka Jpn
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Takeda Tsuyoshi
Department Of Geriatric Medicine Osaka University Graduate School Of Medicine
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竹田 毅
Department of Sports Clinic, School of Medicine, Keio University
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YEH James
Metabolism Laboratory, Department of Medicine, Winthrop-University Hospital
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Iwamoto J
Institute For Integrated Sports Medicine Keio University School Of Medicine
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Yeh James
Metabolism Laboratory Department Of Medicine Winthrop-university Hospital
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YAMADA HARUMOTO
Department of Orthopaedic Surgery, Fujita Health University
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Iwamoto Jun
Department Of Sports Medicine Keio University School Of Medicine
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Iwamoto Jun
Department Of Orthopaedic Surgery School Of Medicine Keio University
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SEKI Azusa
Hamri Corporation
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TAKEDA Tsuyoshi
Institute for Integrated Sports Medicine, Keio University School of Medicine
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Seki Azusa
Hamri Co. Ltd.
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Takeda Tsuyoshi
Institute For Integrated Sports Medicine Keio University School Of Medicine
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Yamada Harumoto
Department Of Orthopaedic Surgery Fujita Health University
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Takeda Tsuyoshi
Department Of Electrical And Electronic Engineering Faculty Of Mining Akita University
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Sato Yoshihiro
Department Of Materials Science And Engineering Faculty Of Engineering Osaka University
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Sato Yuki
Department Of Integrated Biosciences Graduate School Of Frontier Sciences The University Of Tokyo
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Sato Yoshihiro
Department Of Biochemistry Kyoritsu College Of Pharmacy
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関 あずさ
Hamri Co., Ltd.
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Sato Yoshihiro
Department of Applied Biological Science, Tokyo University of Science
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