Beneficial Effects of Combined Administration of Alendronate and Alfacalcidol on Cancellous Bone Mass of the Tibia in Orchidectomized Rats : A Bone Histomorphometry Study
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概要
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The purpose of the present study was to examine the effects of combined administration of alendronate (ALN) and alfacalcidol (ALF) on the cancellous and cortical bone mass of the tibia in orchidectomized rats. Fifty male Sprague-Dawley rats, 3 mo of age, were randomized by the stratified weight method into five groups: age-matched control, orchidectomy, and orchidectomy with administration of ALN (2.5 μg/kg, s.c., 5 times a week), ALF (0.05 μg/kg, p.o., 5 times a week), or ALN+ALF. The total experimental period was 12 wk. Orchidectomy reduced the cancellous bone mass of the proximal tibial metaphysis and maturation-related cortical bone gain of the tibial diaphysis as a result of increased trabecular bone resorption and decreased periosteal bone formation and also increased endocortical bone erosion and formation. ALN suppressed trabecular bone resorption and endocortical bone erosion and formation and increased periosteal bone formation, while ALF increased the number of osteoblasts and suppressed trabecular bone resorption and markedly increased periosteal and endocortical bone formation. Thus, both ALN and ALF prevented the orchidectomy-induced reduction in the cancellous bone mass and maturation-related cortical bone gain. Combined administration of ALN and ALF increased the cancellous bone mass as compared with the values observed in age-matched controls by causing more marked suppression of trabecular bone resorption. The present study showed the beneficial effects of combined administration of ALN and ALF on the cancellous bone mass of the tibia in orchidectomized rats.
- 日本ビタミン学会の論文
著者
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SATO Yoshihiro
Department of Materials Science and Engineering, Faculty of Engineering, Osaka University
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Sato Yoshihiro
Mitate Hospital Fukuoka Jpn
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Takeda Tsuyoshi
Department Of Geriatric Medicine Osaka University Graduate School Of Medicine
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YEH James
Metabolism Laboratory, Department of Medicine, Winthrop-University Hospital
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Iwamoto J
Institute For Integrated Sports Medicine Keio University School Of Medicine
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MATSUMOTO Hideo
Department of Surgery, Division of Gastroenterology, Kawasaki Medical School
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Yeh James
Metabolism Laboratory Department Of Medicine Winthrop-university Hospital
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Iwamoto Jun
Department Of Sports Medicine Keio University School Of Medicine
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Iwamoto Jun
Department Of Orthopaedic Surgery School Of Medicine Keio University
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TAKEDA Tsuyoshi
Institute for Integrated Sports Medicine, Keio University School of Medicine
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MATSUMOTO Hideo
Institute for Integrated Sports Medicine, Keio University School of Medicine
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Matsumoto Hideo
Department Of Orthopaedic Surgery School Of Medicine Keio University
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Takeda Tsuyoshi
Institute For Integrated Sports Medicine Keio University School Of Medicine
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Matsumoto Hideo
Institute For Integrated Sports Medicine Keio University School Of Medicine
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Takeda Tsuyoshi
Department Of Electrical And Electronic Engineering Faculty Of Mining Akita University
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Sato Yoshihiro
Department Of Materials Science And Engineering Faculty Of Engineering Osaka University
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Matsumoto Hideo
Department Of Anesthesiology Kansai Medical University
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Sato Yuki
Department Of Integrated Biosciences Graduate School Of Frontier Sciences The University Of Tokyo
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Sato Yoshihiro
Department Of Biochemistry Kyoritsu College Of Pharmacy
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Sato Yoshihiro
Department of Applied Biological Science, Tokyo University of Science
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